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Imaging butyrylcholinesterase activity in Alzheimer's disease

Kuhl, David E.
Koeppe, Robert A.
Snyder, Scott E.
Minoshima, Satoshi
Frey, Kirk A.
Kilbourn, Michael R.
Kuhl, David E.
Koeppe, Robert A.
Snyder, Scott E.
Minoshima, Satoshi
Frey, Kirk A.
Kilbourn, Michael R.

Publication date

December 2006

DOI

10.1002/ana.21023

Publisher

Wiley

ISSN

0364-5134

Journal

Annals of Neurology

Language

English

Citation count (estimate)

1

Abstract

No abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/55890/1/21023_ftp.pd

Extracted data

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Positron Emission Tomographic Measurement of Brain Acetylcholinesterase Activity Using N-[11C] methylpiperidin-4-yl Acetate Without Arterial Blood Sampling:Methodology of Shape Analysis and its Diagnostic Power for Alzheimer\u27s Disease

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Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease

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March 2021

Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD...

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アセチルコリンアナログを用いた中枢アセチルコリンエステラーゼ活性のin vivo測定

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篠遠仁
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Reduction of central acetylcholinesterase (AChE) activity, that is accompanying with degeneration of...

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Shinoto Hitoshi
Namba Hiroki
Fukushi Kiyoshi
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Irie Toshiaki

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Purpose A neuropathological hallmark of Alzheimer's disease (AD) is the presence of amyloid-β (Aβ) ...

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Fukushi Kiyoshi
Shinotoh Hitoshi
Nagatsuka Shin-ichiro
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Iyo Masaomi
Aotsuka Akiyo
Ota Tsuneyoshi
Tanada Shuji
Irie Toshiaki

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N-[11C] methylpiperidin-4-yl acetate([11C]MP4A) is a radiotracer that has been used successfully for...

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Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease

Rejc, L
Gómez-Vallejo, V
Joya, A
Moreno, O
Egimendia, A
Castellnou, P
Ríos-Anglada, X
Cossío, U
Baz, Z
Passannante, R
Tobalina-Larrea, I
Ramos-Cabrer, P
Giralt, A
Sastre, M
Capetillo-Zarate, E
Košak, U
Knez, D
Gobec, S
Marder, M
Martin, A
Llop, J

March 2021

Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD...

In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses

Kuhl, David E.
Koeppe, Robert A.
Snyder, Scott E.
Minoshima, Satoshi
Frey, Kirk A.
Kilbourn, Michael R.

January 2006

Objective We tested the premise that cholinesterase inhibitor therapy should target butyrylcholines...

Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease

DeBay, Drew R.
Reida, George A.
Pottie, Ian R.
Martin, Earl
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Darvesh, Sultan

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Published versionIntroduction: Diagnosis of Alzheimer's disease (AD) in vivo, by molecular imaging o...

Acetylcholinesterase Imaging: Its Use in Therapy Evaluation and Drug Design

Shinoto Hitoshi
Fukushi Kiyoshi
Nagatsuka Shinnichiro
Irie Toshiaki

January 2004

Several cholinesterase (ChE) inhibitors have been labeled with carbon-11 for visualizing binding sit...

PET probes for imaging brain acetylcholinesterase

Kikuchi Tatsuya
Okamura Toshimitsu
Zhang Ming-Rong
Irie Toshiaki

April 2013

Imaging acetylcholinesterase (AChE) is valuable not only for diagnosing and understanding dementia b...

Synthesis of Piperidinyl and Pyrrolidinyl Butyrates for Potential In Vivo Measurement of Cerebral Butyrylcholinesterase Activity

Kikuchi Tatsuya
Fukushi Kiyoshi
Ikota Nobuo
Ueda Takao
Nagatsuka Shin-ichiro
Arano Yasushi
Irie Toshiaki

January 2001

Biochemical changes in postmortem brains of Alzheimer s diseaase patients include decreased acetylch...

Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates

Namba Hiroki
Fukushi Kiyoshi
Nagatsuka Shin-ichiro
Iyo Masaomi
Shinotoh Hitoshi
Tanada Shuji
Irie Toshiaki

January 2002

A new method for quantitative measurement of brain acetylcholinesterase(AChE) activity in living hum...

Imaging Brain Cholinergic Activity with Positron Emission Tomography

Nora D. Volkow
Yu-shin Ding
Joanna S. Fowler
Samuel J. Gatley

January 2001

One of the strategies in the treatment of Alzheimer’s disease is the use of drugs that enhance choli...

SYNTHESIS AND EVALUATION OF F-18-FEtP4A: A PET TRACER FOR IMAGING BRAIN ACETYLCHOLOLINESTERASE IN VIVO

Zhang Ming-Rong
Tsuchiyama Akio
Kikuchi Tatsuya
Furutsuka Kenji
Yoshida Yuichirou
Kida Takayo
Noguchi Junko
Haradahira Terushi
Irie Toshiaki
Suzuki Kazutoshi

February 2019

AIMS:Postmortem studies in patients with Alzheimer\u27s disease showed a reduction in the activity o...

N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography

Kikuchi Tatsuya
Zhang Ming-Rong
Ikota Nobuo
Fukushi Kiyoshi
Okamura Toshimitsu
Suzuki Kazutoshi
Arano Yasushi
Irie Toshiaki

January 2004

In Alzheimer\u27s disease, cerebral cortical butyrylcholinesterase (BChE) activity is reported to be...

アセチルコリンアナログを用いた中枢アセチルコリンエステラーゼ活性のin vivo測定

長塚伸一郎
難波宏樹
篠遠仁
伊豫雅臣
福士清
入江俊章

January 1999

Reduction of central acetylcholinesterase (AChE) activity, that is accompanying with degeneration of...

Brain Acetylcholinesterase Activity in Alzheimer Disease Measure by Positron Emission Tomography

Shinoto Hitoshi
Namba Hiroki
Fukushi Kiyoshi
Nagatsuka Shinnichiro
Tanaka Noriko
Aotsuka Akiyo
Tanada Shuji
Irie Toshiaki

January 2000

Brain acetylcholinesterase activity was measured in 14 patients with Alzheimer disease and 14 age-ma...

Synthesis and Initial Characterization of a Reversible, Selective \(^{18}\)F-Labeled Radiotracer for Human Butyrylcholinesterase

Gentzsch, Christian
Chen, Xinyu
Spatz, Philipp
Košak, Urban
Knez, Damijan
Nose, Naoko
Gobec, Stanislav
Higuchi, Takahiro
Decker, Michael

January 2021

Purpose A neuropathological hallmark of Alzheimer's disease (AD) is the presence of amyloid-β (Aβ) ...

Positron Emission Tomographic Measurement of Brain Acetylcholinesterase Activity Using N-[11C] methylpiperidin-4-yl Acetate Without Arterial Blood Sampling:Methodology of Shape Analysis and its Diagnostic Power for Alzheimer\u27s Disease

Tanaka Noriko
Fukushi Kiyoshi
Shinotoh Hitoshi
Nagatsuka Shin-ichiro
Namba Hiroki
Iyo Masaomi
Aotsuka Akiyo
Ota Tsuneyoshi
Tanada Shuji
Irie Toshiaki

January 2001

N-[11C] methylpiperidin-4-yl acetate([11C]MP4A) is a radiotracer that has been used successfully for...

Effect of stereochemistry on ester hydrolysis by cholinesterases: Implications for radiotracer design

Snyder, Scott E.
Shao, Xia
Lisi, Jacinda M.
Butch, Elizabeth R.
Skaddan, Marc B.
Kilboum, Michael R.

May 2001

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91202/1/2580440138_ftp.pd

Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease

Rejc, L
Gómez-Vallejo, V
Joya, A
Moreno, O
Egimendia, A
Castellnou, P
Ríos-Anglada, X
Cossío, U
Baz, Z
Passannante, R
Tobalina-Larrea, I
Ramos-Cabrer, P
Giralt, A
Sastre, M
Capetillo-Zarate, E
Košak, U
Knez, D
Gobec, S
Marder, M
Martin, A
Llop, J

March 2021

Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD...