Diabetes is a serious metabolic disorder that according to the International Diabetes Federation (IDF) 2012 report affects about 371 million of people worldwide. This number is likely to increase in the next years especially due to the contribution of the emerging countries where health care is less effective. That is the reason why in these years scientific research has been carried out intensely facing diabetes with different field expertise from cellular biology to pharmacology to engineering and so on. Various scientific questions were answered but still many others are to come. For instance, different tests were developed to study the glucose-insulin system in vivo whose data were analyzed with model based approaches to extrapolate som...
The minimal model of glucose kinetics interprets blood glucose and insulin concentrations after an i...
Glucose minimal model parameters are commonly estimated by applying weighted nonlinear least squares...
The nonlinear mixed effects models (NLMEM) are widespread modeling techniques in PKPD analysis and e...
Diabetes is a serious metabolic disorder that according to the International Diabetes Federation (ID...
Population approaches, traditionally employed in pharmacokinetic-pharmacodynamic studies, have shown...
The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to understan...
Intravenous glucose tolerance test (IVGTT) minimal model parameters are commonly estimated by weight...
Current closed-loop insulin delivery methods stem from sophisticated models of the glucose-insulin (...
Diabetes mellitus is a common disease where a person has high blood glucose levels. The disease has ...
Population kinetic modeling approaches, implemented as nonlinear mixed effects models, are attractin...
Type 2 diabetes is a complex chronic metabolic disorder characterized by hyperglycemia associated wi...
Despite the great progress made in insulin preparation and titration, many patients with diabetes ar...
Several models have been proposed to describe the glucose system at whole-body, organ/tissue and cel...
Blood glucose is controlled by a complex system of insulin and other hormones to assure a constant s...
AbstractThe development of adequate mathematical models for blood glucose dynamics may improve early...
The minimal model of glucose kinetics interprets blood glucose and insulin concentrations after an i...
Glucose minimal model parameters are commonly estimated by applying weighted nonlinear least squares...
The nonlinear mixed effects models (NLMEM) are widespread modeling techniques in PKPD analysis and e...
Diabetes is a serious metabolic disorder that according to the International Diabetes Federation (ID...
Population approaches, traditionally employed in pharmacokinetic-pharmacodynamic studies, have shown...
The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to understan...
Intravenous glucose tolerance test (IVGTT) minimal model parameters are commonly estimated by weight...
Current closed-loop insulin delivery methods stem from sophisticated models of the glucose-insulin (...
Diabetes mellitus is a common disease where a person has high blood glucose levels. The disease has ...
Population kinetic modeling approaches, implemented as nonlinear mixed effects models, are attractin...
Type 2 diabetes is a complex chronic metabolic disorder characterized by hyperglycemia associated wi...
Despite the great progress made in insulin preparation and titration, many patients with diabetes ar...
Several models have been proposed to describe the glucose system at whole-body, organ/tissue and cel...
Blood glucose is controlled by a complex system of insulin and other hormones to assure a constant s...
AbstractThe development of adequate mathematical models for blood glucose dynamics may improve early...
The minimal model of glucose kinetics interprets blood glucose and insulin concentrations after an i...
Glucose minimal model parameters are commonly estimated by applying weighted nonlinear least squares...
The nonlinear mixed effects models (NLMEM) are widespread modeling techniques in PKPD analysis and e...