In migrating cells, the Arp2/3 complex generates branched actin networks that power protrusion of the leading edge in a structure called lamellipodium. The Arp2/3 complex is activated at the leading edge by the Wave complex which is itself activated by the small GTPase Rac. WAVE which is in an inactive state, then exposes its WCA domain (WH2-Connector-Acidic) that can bind to the Arp2/3 complex and activate it to trigger the formation of a new daughter actin filament. This signalling pathway of the Arp2/3 complex has been well studied. However, cell migration is a fine-tuned process that is probably regulated in a more complex manner.To identify new regulators of cell migration, especially proteins that bind to the Arp2/3 complex, we perfor...
International audienceArpin is an Arp2/3 inhibitory protein, which decreases the protrusion lifetime...
SummaryAccurate cell migration requires intricate control over the actin cytoskeleton. Recent work h...
During cell migration, the RAC1-WAVE-ARP2/3 signaling pathway induces the network of branched actin,...
Dans une cellule en migration, la polymérisation d'actine permet de projeter la membrane plasmique d...
At the leading edge, membrane protrusions called lamellipodia are driven by Arp2/3-mediated actin po...
International audienceCell migration requires the generation of branched actin networks that power t...
International audienceCell migration requires the generation of branched actin networks that power t...
International audienceBranched actin networks generated by the Arp2/3 complex provide the driving fo...
The evolutionarily conserved Arp2/3 complex plays a central role in nucleating the branched actin fi...
International audienceArpin is an Arp2/3 inhibitory protein, which decreases the protrusion lifetime...
SummaryAccurate cell migration requires intricate control over the actin cytoskeleton. Recent work h...
During cell migration, the RAC1-WAVE-ARP2/3 signaling pathway induces the network of branched actin,...
Dans une cellule en migration, la polymérisation d'actine permet de projeter la membrane plasmique d...
At the leading edge, membrane protrusions called lamellipodia are driven by Arp2/3-mediated actin po...
International audienceCell migration requires the generation of branched actin networks that power t...
International audienceCell migration requires the generation of branched actin networks that power t...
International audienceBranched actin networks generated by the Arp2/3 complex provide the driving fo...
The evolutionarily conserved Arp2/3 complex plays a central role in nucleating the branched actin fi...
International audienceArpin is an Arp2/3 inhibitory protein, which decreases the protrusion lifetime...
SummaryAccurate cell migration requires intricate control over the actin cytoskeleton. Recent work h...
During cell migration, the RAC1-WAVE-ARP2/3 signaling pathway induces the network of branched actin,...