Changes in glucose transporter expression in glomerular cells occur early in diabetes. These changes, especially the GLUT1 increase in mesangial cells, appear to play a pathogenic role in the development of ECM expansion and perhaps other features of diabetic nephropathy. In addition, it appears that at least some diabetic patients may be predisposed to nephropathy because of polymorphisms in their GLUT1 genes. GLUT1 overexpression leads to increased glucose metabolic flux which in turn triggers the polyol pathway and activation of PKCα and Β1. Activation of these PKC isoforms can lead directly to AP-1 induced increases in fibronectin expression and ECM accumulation. Other, more novel effects of GLUT1 on cellular hypertrophy and injury coul...
Background. Although diabetic nephropathy (DN) is the most common cause for end-stage renal disease ...
What is the central question of this study? Although SGLT2 inhibitors represent a promising treatmen...
Role of GLUT1 gene in susceptibility to diabetic nephropathy in type 2 diabetes.BackgroundThe XbaI p...
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause o...
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause o...
Diabetic nephropathy is a consequence of hyperglycaemia-induced renal cell damage and a major contri...
Glucose transporter (GLUT1) allele (XbaI–) associated with nephropathy in non-insulin-dependent diab...
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause o...
Polymorphisms of the glucose transporter (GLUT1) gene are associated with diabetic nephropathy.Backg...
Glucose transporter (GLUT1) allele (XbaI–) associated with nephropathy in non-insulin-dependent diab...
Polymorphisms of the glucose transporter (GLUT1) gene are associated with diabetic nephropathy.Backg...
Mesangial cells (MCs) play a central role in the pathogenesis of diabetic nephropathy (DN). MC dysfu...
Molecular mechanisms of diabetic renal hypertrophy. Altered growth of renal cells is one of the earl...
Insufficient insulin secretion and insulin resistance are hallmarks of diabetes. Recent studies indi...
Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes, and elev...
Background. Although diabetic nephropathy (DN) is the most common cause for end-stage renal disease ...
What is the central question of this study? Although SGLT2 inhibitors represent a promising treatmen...
Role of GLUT1 gene in susceptibility to diabetic nephropathy in type 2 diabetes.BackgroundThe XbaI p...
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause o...
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause o...
Diabetic nephropathy is a consequence of hyperglycaemia-induced renal cell damage and a major contri...
Glucose transporter (GLUT1) allele (XbaI–) associated with nephropathy in non-insulin-dependent diab...
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause o...
Polymorphisms of the glucose transporter (GLUT1) gene are associated with diabetic nephropathy.Backg...
Glucose transporter (GLUT1) allele (XbaI–) associated with nephropathy in non-insulin-dependent diab...
Polymorphisms of the glucose transporter (GLUT1) gene are associated with diabetic nephropathy.Backg...
Mesangial cells (MCs) play a central role in the pathogenesis of diabetic nephropathy (DN). MC dysfu...
Molecular mechanisms of diabetic renal hypertrophy. Altered growth of renal cells is one of the earl...
Insufficient insulin secretion and insulin resistance are hallmarks of diabetes. Recent studies indi...
Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes, and elev...
Background. Although diabetic nephropathy (DN) is the most common cause for end-stage renal disease ...
What is the central question of this study? Although SGLT2 inhibitors represent a promising treatmen...
Role of GLUT1 gene in susceptibility to diabetic nephropathy in type 2 diabetes.BackgroundThe XbaI p...