Effects of psychoactive agents on acquisition of conditioned pole jumping in rats

Albino rats required progressively more trials to reach a 90 percent avoidance criterion and achieved less mean total percent avoidance learning than saline injected controls following administration of increasing doses of LSD-25, phencyclidine and amobarbital. The psychotomimetics were effective in depressing acquisition in dosages demonstrated by others to be ineffective in overtrained animals. In contrast d-amphetamine had a slight facilitating effect, but only in large doses.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46429/1/213_2004_Article_BF00407861.pd