The effects of chlorpromazine on psychomotor stimulant self-administration in the Rhesus monkey

The effects of acute and chronic chlorpromazine treatment on psychomotor stimulant self-administration behavior in the Rhesus monkey were determined. Chlorpromazine treatment significantly increased the frequency of self-administration of cocaine, pipradrol, phenmetrazine, d -amphetamine and methylphenidate. The basis of this effect was thought to either be due to an antagonism of the reinforcing effect of these compounds or an antagonism of those actions of the psychomotor stimulants which may function in limiting their self-administration.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46383/1/213_2004_Article_BF00422098.pd