The importance of the Rho-GTPases in cancer progression, particularly in the area of metastasis, is becoming increasingly evident. This review will provide an overview of the role of the Rho-regulatory proteins in breast cancer metastatis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44220/1/10549_2004_Article_5264599.pd
Involvement of Rho GTPases in cancer has been a matter of debate since the identification of the fir...
For many years, cancer-associated mutations in RHO GTPases were not identified and observations sugg...
The high incidence of overexpression of some members of the Rho family of GTPases in human tumors su...
Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin cytoskeleton. T...
The importance of the Rho-GTPases in cancer progression, particularly in the area of metastasis, is ...
BACKGROUND: Relatively few genes have been shown to directly affect the metastatic phenotype of brea...
Malignant carcinomas are often characterized by metastasis, the movement of carcinoma cells from a p...
AbstractRho GTPases contribute to multiple cellular processes that could affect cancer progression, ...
Breast cancer is one of the most commonly diagnosed cancers in women around the world. In general, t...
Malignant carcinomas are often characterized by metastasis, the movement of carcinoma cells from a p...
BACKGROUND: The 2 closely related small GTPases, RHOC and RHOA, are involved in mammary gland carci...
Rho GTPases are a family of small G proteins that regulate a wide array of cellular processes relate...
Breast cancer lethality is primarily due to cancer cell metastasis away from the primary tumor to vi...
RHO GTPases have been traditionally associated with protumorigenic functions. While this paradigm is...
PURPOSE: Rho family members are small GTPases that are known to regulate malignant transformation an...
Involvement of Rho GTPases in cancer has been a matter of debate since the identification of the fir...
For many years, cancer-associated mutations in RHO GTPases were not identified and observations sugg...
The high incidence of overexpression of some members of the Rho family of GTPases in human tumors su...
Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin cytoskeleton. T...
The importance of the Rho-GTPases in cancer progression, particularly in the area of metastasis, is ...
BACKGROUND: Relatively few genes have been shown to directly affect the metastatic phenotype of brea...
Malignant carcinomas are often characterized by metastasis, the movement of carcinoma cells from a p...
AbstractRho GTPases contribute to multiple cellular processes that could affect cancer progression, ...
Breast cancer is one of the most commonly diagnosed cancers in women around the world. In general, t...
Malignant carcinomas are often characterized by metastasis, the movement of carcinoma cells from a p...
BACKGROUND: The 2 closely related small GTPases, RHOC and RHOA, are involved in mammary gland carci...
Rho GTPases are a family of small G proteins that regulate a wide array of cellular processes relate...
Breast cancer lethality is primarily due to cancer cell metastasis away from the primary tumor to vi...
RHO GTPases have been traditionally associated with protumorigenic functions. While this paradigm is...
PURPOSE: Rho family members are small GTPases that are known to regulate malignant transformation an...
Involvement of Rho GTPases in cancer has been a matter of debate since the identification of the fir...
For many years, cancer-associated mutations in RHO GTPases were not identified and observations sugg...
The high incidence of overexpression of some members of the Rho family of GTPases in human tumors su...