The recognition of recurring sites of chromosome changes in malignancies has greatly facilitated the identification of genes implicated in the pathogenesis of human cancers. Based especially upon recent studies [1–4], it appears increasingly likely that a subset of recurring chromosome alterations will be recognized in human breast cancer. Currently recognized chromosome changes characterizing breast carcinoma include the recognition of cytologic features of gene amplification (e.g. double minutes [dmins] and homogeneously staining regions [HSRs]) [5–8]. As these and other chromosome regions are implicated in recurring abnormalities in breast cancer, it will become increasingly important to have band-or region-specific genomic libraries and...
Malignant melanoma is frequently characterized by the deletion of the long arm of chromosome 6 (usua...
DNA fingerprinting by arbitrarily primed PCR (AP-PCR) was employed to identify molecular genetic alt...
Despite of the large number of molecular studies in breast cancer, the data are still insufficient f...
Minisymposium on “Molecular Genetics in Breast Cancer”The recognition of recurring sites of chromoso...
We have performed microdissection of 16 putative homogeneously staining regions (hsrs) from nine dif...
Cytogenetic analysis was performed on 50 short-term culture of human ovarian carcinoma from 48 patie...
DNA sequence amplification contributes to the multistep process of carcinogenesis, and overexpressio...
This journal issue contain Abstracts of the 4th Nottingham International Breast Cancer Conference .....
We have developed a modified strategy for the generation of regional probes for human chromosomes by...
Gene amplification is an important manifestation of genetic instability in cancer. Recently, the stu...
In human breast carcinomas, increased copy number of DNA sequences derived from the long arm of chro...
BRCA1 is a major gatekeeper of genomic stability. Acting in multiple central processes like double-s...
Chromosome microdissection was utilised for the analysis of cytogenetic markers of gene amplificatio...
Chromosome 1 copy number in the benign breast lesions hyperplasia and atypical duct hyperplasia (ADH...
The strategy presented here to identify unequivocally cryptic chromosomal rearrangements has relevan...
Malignant melanoma is frequently characterized by the deletion of the long arm of chromosome 6 (usua...
DNA fingerprinting by arbitrarily primed PCR (AP-PCR) was employed to identify molecular genetic alt...
Despite of the large number of molecular studies in breast cancer, the data are still insufficient f...
Minisymposium on “Molecular Genetics in Breast Cancer”The recognition of recurring sites of chromoso...
We have performed microdissection of 16 putative homogeneously staining regions (hsrs) from nine dif...
Cytogenetic analysis was performed on 50 short-term culture of human ovarian carcinoma from 48 patie...
DNA sequence amplification contributes to the multistep process of carcinogenesis, and overexpressio...
This journal issue contain Abstracts of the 4th Nottingham International Breast Cancer Conference .....
We have developed a modified strategy for the generation of regional probes for human chromosomes by...
Gene amplification is an important manifestation of genetic instability in cancer. Recently, the stu...
In human breast carcinomas, increased copy number of DNA sequences derived from the long arm of chro...
BRCA1 is a major gatekeeper of genomic stability. Acting in multiple central processes like double-s...
Chromosome microdissection was utilised for the analysis of cytogenetic markers of gene amplificatio...
Chromosome 1 copy number in the benign breast lesions hyperplasia and atypical duct hyperplasia (ADH...
The strategy presented here to identify unequivocally cryptic chromosomal rearrangements has relevan...
Malignant melanoma is frequently characterized by the deletion of the long arm of chromosome 6 (usua...
DNA fingerprinting by arbitrarily primed PCR (AP-PCR) was employed to identify molecular genetic alt...
Despite of the large number of molecular studies in breast cancer, the data are still insufficient f...