Although the presence or absence of somatic mutations in the immunoglobulin variable region (IgVH) genes in chronic lymphocytic leukemia (B-CLL) identifies subtypes with very different prognoses, the assay is technically complex and unavailable to most laboratories. CD38 expression has been suggested as a surrogate marker for the 2 subtypes. IgVH mutations and CD38 expression in 145 patients with B-CLL with a long follow-up were compared. The 2 assays gave discordant results in 41 patients (28.3%). Multivariate analysis demonstrated that Binet stage, IgVH mutations and CD38 were independent prognostic indicators. Median survival time in patients whose cells had unmutated IgVH genes and expressed CD38 was 8 years; in those with mutated IgVH ...
Background: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Europe and i...
Abstract— Chronic lymphocytic leukemia (CLL) is considered the most common B-cell leukemia. Its clin...
Recognition of biased immunoglobulin variable (IgV) gene usage in B-cell chronic lymphocytic leukemi...
Mutational status of immunoglobulin heavy-chain variable-region (IgVH) genes, along with CD38 expres...
Background: In this study, we aimed to determine a cutoff level for CD38 that would aid us in identi...
Background and objectives: to investigate whether CD38 expression at diagnosis is an independent pre...
The purpose of this study was to assess in chronic lymphocytic leukaemia (CLL) patients the prevalen...
The clinical heterogeneity that characterizes chronic lymphocytic leukemia (CLL) poses critical ques...
The clinical heterogeneity that characterizes chronic lymphocytic leukemia (CLL) poses critical ques...
CD38 expression of tumor cells has been identified as an important prognostic factor in B-cell chron...
ZAP-70, CD38 and IGHV mutations have all been reported to have prognostic impact in chronic lymphocy...
Recent studies have shown that the somatic mutation status of the immunoglobulin (Ig) VH genes can d...
Chronic lymphocytic leukemia (CLL) is the most frequent leukemic disease of adults in the Western wo...
CD38 rules proliferation signals in chronic lymphocytic leukemia (CLL) cells, suggesting that the mo...
CD38 expression is an important prognostic marker in chronic lymphocytic leukemia (CLL) with high le...
Background: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Europe and i...
Abstract— Chronic lymphocytic leukemia (CLL) is considered the most common B-cell leukemia. Its clin...
Recognition of biased immunoglobulin variable (IgV) gene usage in B-cell chronic lymphocytic leukemi...
Mutational status of immunoglobulin heavy-chain variable-region (IgVH) genes, along with CD38 expres...
Background: In this study, we aimed to determine a cutoff level for CD38 that would aid us in identi...
Background and objectives: to investigate whether CD38 expression at diagnosis is an independent pre...
The purpose of this study was to assess in chronic lymphocytic leukaemia (CLL) patients the prevalen...
The clinical heterogeneity that characterizes chronic lymphocytic leukemia (CLL) poses critical ques...
The clinical heterogeneity that characterizes chronic lymphocytic leukemia (CLL) poses critical ques...
CD38 expression of tumor cells has been identified as an important prognostic factor in B-cell chron...
ZAP-70, CD38 and IGHV mutations have all been reported to have prognostic impact in chronic lymphocy...
Recent studies have shown that the somatic mutation status of the immunoglobulin (Ig) VH genes can d...
Chronic lymphocytic leukemia (CLL) is the most frequent leukemic disease of adults in the Western wo...
CD38 rules proliferation signals in chronic lymphocytic leukemia (CLL) cells, suggesting that the mo...
CD38 expression is an important prognostic marker in chronic lymphocytic leukemia (CLL) with high le...
Background: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Europe and i...
Abstract— Chronic lymphocytic leukemia (CLL) is considered the most common B-cell leukemia. Its clin...
Recognition of biased immunoglobulin variable (IgV) gene usage in B-cell chronic lymphocytic leukemi...