Vascular reactivity in hypertension: Altered effect of ouabain

Ouabain inhibits the relaxing effect of Ca 2+ (but not of Mn 2+ ) on contractile responses in tail artery strips isolated from spontaneously hypertensive and normotensive rats. The magnitude of ouabain inhibition was greater in vascular strips from hypertensive rats suggesting a significant difference in basic membrane function in hypertensive vascular smooth muscle.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42713/1/18_2005_Article_BF01953743.pd