The relationship between cell cycle progression and induction of DNA double-strand breaks and cytotoxicity by exposure to fluorodeoxyuridine (FdUrd) was studied in HT29 human colon cancer cells. Fractionation of drug-treated populations by centrifugal elutriation yielded subpopulations having widely divergent abilities to progress through S phase in the presence of the drug. One of these subpopulations, which appeared to undergo coordinated growth arrest, was resistant to FdUrd cytotoxicity and DNA damage. In contrast, the subpopulation which was able to progress furthest through S phase in the presence of FdUrd underwent unbalanced growth arrest (i.e., increase in size and mass out of proportion to DNA synthesis), and displayed both DNA d...
Abstract Background Evidence suggests that tumor cells exposed to some DNA damaging agents are more ...
BACKGROUND AND PURPOSE: To try to get a better insight on the interaction between dFdC and ionizing ...
Fludarabine (FLU, a fluorinated purine analog) and idarubicin (IDA, a DNA-topoisomerase II poison) a...
5-Fluoro-2$\sp\prime$-deoxyuridine (FdUrd) is widely used in the treatment for solid tumors, as a ch...
Current evidence suggests that DNA damage plays an integral role in mediating cytotoxicity that resu...
The cytokinetic and biochemical effects of 5-fluorouracil and 5-fluorouridine were exam-med in a hum...
We have reported that HT29 colon cancer cells, which are radiosensitized by fluorodeoxyuridine (FdUr...
We have reported that HT29 colon cancer cells, which ()are radiosensitized by fluorodeoxyuridine FdU...
AbstractWe have reported that HT29 colon cancer cells, which are radiosensitized by fluorodeoxyuridi...
Acquired chemoresistance is one of the obstacles for success of 5-fluorouracil (5-FU)-based cancer c...
Radio-iododeoxyuridine (IdUrd) is a potential Auger radiation therapy agent incorporated into DNA du...
Thymidylate synthase (TS) is an important target for chemotherapy and can be inhibited by 5-fluorour...
The modes of action of 5-fluoro-2′-deoxyuridine (FdUrd) and 5-fluoro-2′-deoxycytidine (FdCyd) were s...
ABSTRACT-5-Fluoro-2'-deoxyuridine (FdUrd) lowered the dTIP levels in rapidly frozen 12-day W ra...
PURPOSE: Radio-iododeoxyuridine (IdUrd) is a potential Auger radiation therapy agent incorporated in...
Abstract Background Evidence suggests that tumor cells exposed to some DNA damaging agents are more ...
BACKGROUND AND PURPOSE: To try to get a better insight on the interaction between dFdC and ionizing ...
Fludarabine (FLU, a fluorinated purine analog) and idarubicin (IDA, a DNA-topoisomerase II poison) a...
5-Fluoro-2$\sp\prime$-deoxyuridine (FdUrd) is widely used in the treatment for solid tumors, as a ch...
Current evidence suggests that DNA damage plays an integral role in mediating cytotoxicity that resu...
The cytokinetic and biochemical effects of 5-fluorouracil and 5-fluorouridine were exam-med in a hum...
We have reported that HT29 colon cancer cells, which are radiosensitized by fluorodeoxyuridine (FdUr...
We have reported that HT29 colon cancer cells, which ()are radiosensitized by fluorodeoxyuridine FdU...
AbstractWe have reported that HT29 colon cancer cells, which are radiosensitized by fluorodeoxyuridi...
Acquired chemoresistance is one of the obstacles for success of 5-fluorouracil (5-FU)-based cancer c...
Radio-iododeoxyuridine (IdUrd) is a potential Auger radiation therapy agent incorporated into DNA du...
Thymidylate synthase (TS) is an important target for chemotherapy and can be inhibited by 5-fluorour...
The modes of action of 5-fluoro-2′-deoxyuridine (FdUrd) and 5-fluoro-2′-deoxycytidine (FdCyd) were s...
ABSTRACT-5-Fluoro-2'-deoxyuridine (FdUrd) lowered the dTIP levels in rapidly frozen 12-day W ra...
PURPOSE: Radio-iododeoxyuridine (IdUrd) is a potential Auger radiation therapy agent incorporated in...
Abstract Background Evidence suggests that tumor cells exposed to some DNA damaging agents are more ...
BACKGROUND AND PURPOSE: To try to get a better insight on the interaction between dFdC and ionizing ...
Fludarabine (FLU, a fluorinated purine analog) and idarubicin (IDA, a DNA-topoisomerase II poison) a...