Backgrund & Objectives: The aim of this study was to evaluate the role of mutations in codon 305 in katG gene in isoniazid resistant phenotype. Methods: A region containing codon 305 of katG gene was amplified by PCR. GGC to GCC mutation was detected by BanI endonuclease. The results were compared with the results of drug susceptibility testing with Mycobacteria growth indicator tube (MGIT). Results: 26 isolates were resistant to isoniazid by MGIT. Of these, 4 isolates had mutations in codon 305. Specificity of this endonuclease to identify resistant cases, was estimated to be 98%. Conclusion: BanI endonuclease was able to detect 15% of cases resistant to isoniazid (4 of 26 resistant). BanI endonuclease has a high specificity to identif...
Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifical...
<p><i>Strains are identified by the name given by either the RIVM (numerical codes) or the KIT (lett...
Background: The molecular prediction of isoniazid (INH) resistance in Mycobac-terium tuberculosis ha...
Copyright © 2015 A. Nusrath Unissa et al. This is an open access article distributed under the Creat...
Mutation at codon 315 of katG gene is the major cause for isoniazid (INH) resistance in Mycobacteriu...
Isoniazid (INH) is a central component of drug regimens used worldwide to treat tuberculosis. In res...
Abstract The KatG gene of Mycobacterium Tuberculosis has been associated with isoniazid (INH) drug r...
Emergence of multidrug resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (...
The aim of this study was to investigate the frequency, location and type of katG mutations in Myc...
Mycobacterium tuberculosis resistant strains is a matter of great concern for TB control Program sin...
Elucidation of the molecular basis of isoniazid (INH) resistance in Mycobacterium tuberculosis has l...
AbstractBackgroundBy using whole genome sequencing (WGS), researchers are beginning to understand th...
<div><p>Background</p><p>Isoniazid (INH) is a highly effective antibiotic central for the treatment ...
C1 - Journal Articles RefereedElucidation of the molecular basis of isoniazid (INH) resistance in My...
In a recent article (7), we reported the results of mutational analysis of katG in isoniazid-resist...
Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifical...
<p><i>Strains are identified by the name given by either the RIVM (numerical codes) or the KIT (lett...
Background: The molecular prediction of isoniazid (INH) resistance in Mycobac-terium tuberculosis ha...
Copyright © 2015 A. Nusrath Unissa et al. This is an open access article distributed under the Creat...
Mutation at codon 315 of katG gene is the major cause for isoniazid (INH) resistance in Mycobacteriu...
Isoniazid (INH) is a central component of drug regimens used worldwide to treat tuberculosis. In res...
Abstract The KatG gene of Mycobacterium Tuberculosis has been associated with isoniazid (INH) drug r...
Emergence of multidrug resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (...
The aim of this study was to investigate the frequency, location and type of katG mutations in Myc...
Mycobacterium tuberculosis resistant strains is a matter of great concern for TB control Program sin...
Elucidation of the molecular basis of isoniazid (INH) resistance in Mycobacterium tuberculosis has l...
AbstractBackgroundBy using whole genome sequencing (WGS), researchers are beginning to understand th...
<div><p>Background</p><p>Isoniazid (INH) is a highly effective antibiotic central for the treatment ...
C1 - Journal Articles RefereedElucidation of the molecular basis of isoniazid (INH) resistance in My...
In a recent article (7), we reported the results of mutational analysis of katG in isoniazid-resist...
Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifical...
<p><i>Strains are identified by the name given by either the RIVM (numerical codes) or the KIT (lett...
Background: The molecular prediction of isoniazid (INH) resistance in Mycobac-terium tuberculosis ha...