The Effect of Preoperative Ondansetron in Reducing of Nausea and Vomitting after Loparoscopic Cholescystectomy

Background: Postoperative nausea and vomiting (PONV) is one of the most common complications of anesthesia and without prophylactic intervention occurs by about one-third of patients under general anesthesia. The aim of this study was to compare the efficacy of ondansetron and metoclopramide in reducing PONV after laparoscopic cholecystectomy. Methods: In this study, 90 patients undergoing laparoscopic cholecystectomy were randomly allocated into three equal groups (n=30) and in the first group 10 mg metoclopramide, in the second group 4 mg ondansetron and for placebo group 2 cc normal saline preoperatively were injected. Anesthesia complications in recovery and nausea and vomiting in recovery and 6 hour and 24 hour after surgery were evaluated. Data were analyzed by SPSS software with chi-square test and analysis of variance (ANOVA). P