Compare of Intra nasal Midazolam VS. Chloral Hydrate in sedation of under 5 years old children before Echocardiography

Introduction Echocardiography is a diagnostic and monitoring method in congenital heart disease cause of evaluation of anatomy and physiology of heart.This method, need patient remain calm and sleepiness.Aa we know, it is difficult for children under 5 years old to be in such situation, so a drug, that made children quiet for at least 30 minutes, is necessary. The aim of this study is compare the effects of intranasal Midazolam and Chloral Hydrate in sedation, time effect, success rate in echocardiography etc, in children under 5 years old before echocardiography. Material and Methods This is a clinical trial and carried out on 250 children who referred to pediatric clinic for echocardiography. The subjects were randomly divided into two groups receiving chloral hydrate and midazolam. First, these children parents were asked about demographic information, referring cause and the history of previous illness, Then the drugs was administered in patients groups separately; and the onset of both drugs effects, sedation level, the success rate in echocardiography, the percentage of oxygen saturation, side effects of drugs, type of heart disease and pulmonary artery pressure were recorded in check list, then analyzed by statistical software. Results In this study 59.2% of children who received midazolam were male with 11.60±8.30 month age and 52.8% were in chloral hydrate group with 13.18 months age. Onset of the drug effects started in less than 10 minutes in the midazolam and chloral hydrate recipients that were 97.6 and 2.4% (p<0.001) respectively; full completion of echocardiography were in 84.8 and 60% of children (p<0.001) respectively and also drug side effects was observed in 34 and 75.2% of children (p<0.001) respectively. Vitnessed that sedative effects of midazolam was more superficial than chloral hydrate (p<0.001), midazolam had the lowest saturation drop (p