Comparing the Therapeutic Effect of Clotrimazole 1% Local Cream and Terbinafine Local Cream in Treating of Patients Given to Tinea Corporis and Tinea Cruris

Backgrund & Objectives: Tinea corporis is dermatophytosis infection of skin without hair and Tineacruris, is in fact a type of Tinea corporis .The usual treatment of this two disease, involves the topical application of azoles and allylamines. this study attempts to identify drug that has the most cost- benefit efficacy in between two topical creams ofTerbinafine 1% and Clotrimazole 1%. Methods: Afterward that with preparated smir with positive KOH, dermatophytosis of 100patients with suspicious to Tinea corporis and 50 patients with suspicious to Tinea cruris referred to the Kashan reference laboratory was determined, a portion of culture on SCC medium, is prescripted one of two drugs of terbinafine 1% or clotrimazole 1% local cream, randomly and single blind, twice daily for 2 weeks and providing of requirement 4 weeks; after than 2 and 4 weeks treatment, result of improvement was checked of clinical and laboratory (smir and culture) aspect. Results: In this study, cure rate of Terbinafine to compared with clotrimazole in treatment oftinea corporis and tinea cruris, after 2 weeks treatment, was respectively, 69/3% versus 77.3%with P=0.505. and after 4 weeks treatment (providing of requirement), was respectively, 78.3%versus 70.6% with P=0.849; Also cure rate of Terbinafine to compared with clotrimazole intreatment of tinea corporis, after 2 weeks treatment, was respectively, 64% versus 76% with P=0.432. and after 4 weeks treatment (providing of requirement), was respectively, 72.2% versus 58.3% with P=0.837; Also cure rate of Terbinafine as compared to clotrimazole in treatment of tinea cruris, after 2 weeks treatment, per two groups of therapeutic, was 80% with P=N.S. and after 4 weeks treatment (providing of requirement), per two groups of therapeutic, was 100% with P=N.S. In this study, teminafine afid clotrimazole were significantly effectived in treatment of Trichophyton. mentagrophytes, Trichophytonverrucosum,Trichophytonrubrumand Epidermophytonfloccosum with statistical aspect (P<0.05) but .alone trebinafine were significantly effectived in treatment of Trichophyton rubrum and Microsporum canis with statistical aspect (P<0.03). In sum, among of therapeutic groups is not observed no differentiation in age, sex, occupation,duration of sickness, history of contact with the animal, type of lesion, clinical symptoms,diameter, number and type of fungus (P