Human Intestinal Permeability of Piroxicam, Propranolol, Phenylalanine, and PEG 400 Determined by Jejunal Perfusion
- Lennernäs, Hans
- Shah, Vinod P.
- Barnett, Jeffrey L.
- Lesko, Lawrence J.
- Rhie, Julie K.
- Welage, Lynda S.
- Hayashi, Yayoi
- Takamatsu, Narushi
- Idkaidek, Nasir M.
- Lee, Peter I-Der
- Liu, Dong-Yue
- Amidon, Gordon L.
Publication date
September 1997
DOI Publisher
Springer Science and Business Media LLC Journal
Pharmaceutical ResearchAbstract
Purpose . To determine the human jejunal permeabilities of compounds utilizing different transport mechanisms using a regional perfusion approach and to establish a standard procedure for determining drug permeability class to be used for the establishment of drug product bioequivalence standards.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41460/1/11095_2004_Article_304276.pd
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