Effect of Vehicles and Penetration Enhancers on the In Vitro and In Vivo Percutaneous Absorption of Methotrexate and Edatrexate Through Hairless Mouse Skin

Li, Wen Y.
Koda, Robert T.
Chatterjee, Dhruba J.

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Publication date

August 1997

DOI

10.1023/A:1012109513643

Publisher

Springer Science and Business Media LLC

Journal

Pharmaceutical Research

Abstract

Purpose . Low-dose methotrexate (MTX) is approved for the treatment of recalcitrant rheumatoid arthritis (RA). The objective of this study was to determine the effect of vehicles and penetration enhancers on the percutaneous absorption of MTX and its analog edatrexate (EDAM), and develop transdermal (TD) delivery systems of the drugs for the treatment of RA.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41459/1/11095_2004_Article_304264.pd

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Effect of Vehicles and Penetration Enhancers on the In Vitro and In Vivo Percutaneous Absorption of Methotrexate and Edatrexate Through Hairless Mouse Skin

Abstract

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Effect of Vehicles and Penetration Enhancers on the In Vitro and In Vivo Percutaneous Absorption of Methotrexate and Edatrexate Through Hairless Mouse Skin

Abstract

Extracted data

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