Intratumoral IL-12 and TNF-α–Loaded Microspheres Lead To Regression of Breast Cancer and Systemic Antitumor Immunity

Chang, Wen-Jian
Bailey, Nicola
Sabel, Michael S.
Chang, Alfred E.
Mathiowitz, Edith
Egilmez, Nejat K.
Stoolman, Lloyd M.
Skitzki, Joseph

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Publication date

January 2004

DOI

10.1245/ASO.2004.03.022

Publisher

Springer Science and Business Media LLC

ISSN

1068-9265

Journal

Annals of Surgical Oncology

Abstract

Background: Local, sustained delivery of cytokines at a tumor can enhance induction of antitumor immunity and may be a feasible neoadjuvant immunotherapy for breast cancer. We evaluated the ability of intratumoral poly-lactic-acid-encapsulated microspheres (PLAM) containing interleukin 12 (IL-12), tumor necrosis factor α (TNF-α), and granulocyte-macrophage colony stimulating factor (GM-CSF) in a murine model of breast cancer to generate a specific antitumor response.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41401/1/10434_2004_Article_147.pd

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Intratumoral IL-12 and TNF-α–Loaded Microspheres Lead To Regression of Breast Cancer and Systemic Antitumor Immunity

Abstract

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Intratumoral IL-12 and TNF-α–Loaded Microspheres Lead To Regression of Breast Cancer and Systemic Antitumor Immunity

Abstract

Extracted data

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