Distinctive serum globulin responses to parenteral treatment with 17-Β-estradiol in female NZB/NZW mice

After 6 weeks of treatment with 17-Β-estradiol, two distinct groups of female NZB/NZW mice were identified. Group I females developed significant increases in serum Α 2 , Β- and Γ-globulins and had few serologic abnormalities. Serum globulins did not increase in Group II females. This blunted response correlated with a pretreatment increase in the frequency of positive tests for ANA, LE phenomena and cryoproteins in 4-week-old Group II mice.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/37721/1/1780150107_ftp.pd