Effect of furosemide on glucose metabolism

The administration of furosemide, a benzothiadiazine analogue, to rats results in elevation of the initial and 2-hour postglucose loading blood glucose levels. Furosemide given to rats causes a decrease in the rate of glucose utilization by their adipose tissue in vitro. Furosemide added directly to the incubational medium also decreases the rate of glucose utilization of normal rats' fat tissue in vitro. These effects of furosemide are similar to those produced by chlorothiazide and other benzothiadiazine compounds.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33327/1/0000723.pd