Biosynthesis of phenolic tetrahydroisoquinoline alkaloids of peyote

Data are presented supporting a proposed pathway of biosynthesis of the phenolic tetrahydroisoquinoline alkaloids of peyote from dopamine. It is suggested that meta-O-methylation of dopamine, hydroxylation in the 5-position, para-O-methylation and finally cyclizations yield anhalamine, anhalidine, anhalonidine and pellotine.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32728/1/0000096.pd