A method for the determination of guanidoacetic acid and arginine in biological fluids,

A method for the determination of either arginine or guanidoacetic acid or both in biological materials has been presented. The method is based on the chromatographic separation of arginine from guanidoacetic acid and the direct determination of each compound by the Sakaguchi reaction. The recovery of added compounds to urine, plasma, and kidney extracts ranges from 96.0 to 104.0%.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32445/1/0000527.pd