A study of the biosynthesis of phenazine-1-carboxylic acid

Washed cell preparations of Pseudomonas aureofaciens synthesize phenazine-1-carboxylic acid in a medium consisting of 0.2 M glycerol and 0.02 M-lysine. Experiments with C14-labeled substrates indicate that all of the carbon atoms in the phenazine-1-carboxylic acid are derived from glycerol. Anthranilic acid inhibits synthesis of this phenazine compound. Incorporation of label from H3-shikimic acid has been demonstrated. In addition, a decrease in the incorporation of label from glycerol-1,3-C14 into phenazine-1-carboxylic acid has been demonstrated in the presence of unlabeled shikimic acid.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32163/1/0000218.pd