Metabolism of plasmalogen III. Relative reactivities of acyl and alkenyl derivatives of glycerol-3-phosphorylcholine

1. (1) The alkenyl ether derivatives of phospholipids (plasmalogens) react at slower rates than the acyl analogs in several enzyme-catalyzed reactions.2. (2) Alkenylglycerol-3-phosphorylcholine is essentially inert as a substrate for acyl-CoA: phospholipid acyltransf erase. This result suggests that in vivo the 2-acyl substituent may be present before the alkenyl ether group is formed in the molecule.3. (3) Alkenyl acylglycerol 3-phosphorylcholine is essentially inert as a substrate for cabbage phospholipase D (EC 3.1.4.4.). This lack of reactivity allows a convenient separation of alkenyl acylglycerol 3-phosphorylcholine from its diacyl analog in naturally occurring mixtures.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32018/1/0000060.pd