Cobalamin-dependent methionine synthase is a large enzyme composed of structurally and functionally distinct regions. Recent studies have begun to define the roles of several regions of the protein. In particular, the structure of a 27 kDa cobalamin-binding fragment of the enzyme from Escherichia coli has been determined by X-ray crystallography, and has revealed the motifs and interactions responsible for recognition of the cofactor. The amino acid sequences of several adenosylcobalamin-dependent enzymes, the methylmalonyl coenzyme A mutases and glutamate mutases, show homology with the cobalamin-binding region of methionine synthase and retain conserved residues that are determinants for the binding of the prosthetic group, suggesting tha...
The C-terminal domain of cobalamin-dependent methionine synthase (MetH) has an essential role in cat...
The reduction of methylenetetrahydrofolate (CH2-H4folate) to methyltetrahydrofolate (CH3-H4folate) i...
Methionine is one of the seven essential amino-acids for humans and is also used in feed supplements...
AbstractBackground In both mammalian and microbial species, B12-dependent methionine synthase cataly...
AbstractBackground In both mammalian and microbial species, B12-dependent methionine synthase cataly...
AbstractDetermination of the structure of intact methylmalonyl-CoA mutase from Propionibacterium she...
Cobalamin-dependent methionine synthase (MetH) is a 136 kDa monomeric enzyme that catalyzes methyl t...
Cobalamin-dependent methionine synthase (MetH) is a 136 kDa monomeric enzyme that catalyzes methyl t...
<div><p>Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group fr...
Methyltetrahydrofolate (CH3-H4folate) donates a methyl group to the cob(I)alamin cofactor in the rea...
Homocysteine (Hcy) has been identified as an independent risk factor for a variety of health problem...
Homocysteine (Hcy) has been identified as an independent risk factor for a variety of health problem...
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154369/1/fsb2004005005.pd
Cobalamin-dependent methionine synthase (MetH) is a 136 kDa, modular enzyme that undergoes large con...
Cobalamin-dependent methionine synthase (MetH) is a 136 kDa, modular enzyme that undergoes large con...
The C-terminal domain of cobalamin-dependent methionine synthase (MetH) has an essential role in cat...
The reduction of methylenetetrahydrofolate (CH2-H4folate) to methyltetrahydrofolate (CH3-H4folate) i...
Methionine is one of the seven essential amino-acids for humans and is also used in feed supplements...
AbstractBackground In both mammalian and microbial species, B12-dependent methionine synthase cataly...
AbstractBackground In both mammalian and microbial species, B12-dependent methionine synthase cataly...
AbstractDetermination of the structure of intact methylmalonyl-CoA mutase from Propionibacterium she...
Cobalamin-dependent methionine synthase (MetH) is a 136 kDa monomeric enzyme that catalyzes methyl t...
Cobalamin-dependent methionine synthase (MetH) is a 136 kDa monomeric enzyme that catalyzes methyl t...
<div><p>Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group fr...
Methyltetrahydrofolate (CH3-H4folate) donates a methyl group to the cob(I)alamin cofactor in the rea...
Homocysteine (Hcy) has been identified as an independent risk factor for a variety of health problem...
Homocysteine (Hcy) has been identified as an independent risk factor for a variety of health problem...
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154369/1/fsb2004005005.pd
Cobalamin-dependent methionine synthase (MetH) is a 136 kDa, modular enzyme that undergoes large con...
Cobalamin-dependent methionine synthase (MetH) is a 136 kDa, modular enzyme that undergoes large con...
The C-terminal domain of cobalamin-dependent methionine synthase (MetH) has an essential role in cat...
The reduction of methylenetetrahydrofolate (CH2-H4folate) to methyltetrahydrofolate (CH3-H4folate) i...
Methionine is one of the seven essential amino-acids for humans and is also used in feed supplements...