A six residue polypeptide has been synthesized to study the proposed biosynthesis of lanthionine. It is shown that this peptide spontaneously cyclizes in a biomimetic fashion via a completely stereoselective intramolecular Michael addition to form (2s, 6R)-lanthionine, as found in naturally occurring lantibiotics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30395/1/0000014.pd
Lanthipeptides are ribosomally synthesized and posttranslationally modified peptides produced by mic...
As members of the ribosomally synthesized and post-translationally modified peptide natural products...
ABSTRACT: Lantibiotics are (methyl)lanthionine-containing bacterial peptides. (Methyl)lanthionines a...
Lantibiotics are polycyclic peptide antibiotics, active against a range of gram positive bacteria. T...
200 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.Lantibiotics are ribosomally ...
Recent genome sequencing efforts have revealed that a common biosynthetic route to peptide natural p...
Natural products and natural product derivatives have been the leading source of pharmaceutical comp...
Natural products play important roles in the survival of organisms, and provide a large pool of cand...
New antibiotics are desperately needed to combat the disturbing rise of pathogenic microorganisms re...
Natural products have played prominent roles in science and medicine due to their diverse chemical s...
Peptides are an attractive class of therapeutics, occupying a niche between small molecules and biol...
211 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.Lantibiotics are bacterial-de...
Natural products and their derivatives have been significant resources for the development of therap...
136 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.Lantibiotics are peptide anti...
Lantibiotics are (methyl)lanthionine-containing bacterial peptides. (Methyl)lanthionines are posttra...
Lanthipeptides are ribosomally synthesized and posttranslationally modified peptides produced by mic...
As members of the ribosomally synthesized and post-translationally modified peptide natural products...
ABSTRACT: Lantibiotics are (methyl)lanthionine-containing bacterial peptides. (Methyl)lanthionines a...
Lantibiotics are polycyclic peptide antibiotics, active against a range of gram positive bacteria. T...
200 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.Lantibiotics are ribosomally ...
Recent genome sequencing efforts have revealed that a common biosynthetic route to peptide natural p...
Natural products and natural product derivatives have been the leading source of pharmaceutical comp...
Natural products play important roles in the survival of organisms, and provide a large pool of cand...
New antibiotics are desperately needed to combat the disturbing rise of pathogenic microorganisms re...
Natural products have played prominent roles in science and medicine due to their diverse chemical s...
Peptides are an attractive class of therapeutics, occupying a niche between small molecules and biol...
211 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.Lantibiotics are bacterial-de...
Natural products and their derivatives have been significant resources for the development of therap...
136 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.Lantibiotics are peptide anti...
Lantibiotics are (methyl)lanthionine-containing bacterial peptides. (Methyl)lanthionines are posttra...
Lanthipeptides are ribosomally synthesized and posttranslationally modified peptides produced by mic...
As members of the ribosomally synthesized and post-translationally modified peptide natural products...
ABSTRACT: Lantibiotics are (methyl)lanthionine-containing bacterial peptides. (Methyl)lanthionines a...
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