CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28550/1/0000349.pd