We used multiple sets of simulations both at the atomistic and coarse-grained level of resolution to investigate interaction and binding of α-tochoperol transfer protein (α-TTP) to phosphatidylinositol phosphate lipids (PIPs). Our calculations indicate that enrichment of membranes with such lipids facilitate membrane anchoring. Atomistic models suggest that PIP can be incorporated into the binding cavity of α-TTP and therefore confirm that such protein can work as lipid exchanger between the endosome and the plasma membrane. Comparison of the atomistic models of the α-TTP-PIPs complex with membrane-bound α-TTP revealed different roles for the various basic residues composing the basic patch that is key for the protein/ligand interaction. Su...
Vitamin E is an essential micronutrient. The primary function of this lipid-soluble antioxidant is t...
The cell membrane serves as a barrier between the interior and exterior of a living cell. Its main s...
Phosphatidylinositol transfer protein α (PITPα) selectively transports and promotes exchange of phos...
We used multiple sets of simulations both at the atomistic and coarse-grained level of resolution to...
Interactions between proteins and membranes are central to many signalling pathways and other cellul...
Previous work has shown that the -tocopherol transfer protein ( -TTP) can bind to vesicular or immo...
Peripheral membrane proteins can reversibly and specifically bind to biological membranes to carry o...
Phosphatidylinositol-transfer proteins (PITPs) regulate phosphoinositide signaling in eukaryotic cel...
Peripheral membrane proteins are structurally diverse proteins that are involved in fundamental cell...
The translocator protein (TSPO) is a 18kDa transmembrane protein, ubiquitously present in human mito...
Parallel advances in lipidomics and the structural biology of membrane proteins over the past decade...
SummaryInteractions of membrane proteins with lipid molecules are central to their stability and fun...
Understanding the energetics of peripheral protein-membrane interactions is important to many areas ...
In order to associate with the cytoplasmic leaflet of the plasma membrane, many cytosolic signalling...
Phosphatidylinositol transfer proteins (PITPs) are believed to be lipid transfer proteins due to the...
Vitamin E is an essential micronutrient. The primary function of this lipid-soluble antioxidant is t...
The cell membrane serves as a barrier between the interior and exterior of a living cell. Its main s...
Phosphatidylinositol transfer protein α (PITPα) selectively transports and promotes exchange of phos...
We used multiple sets of simulations both at the atomistic and coarse-grained level of resolution to...
Interactions between proteins and membranes are central to many signalling pathways and other cellul...
Previous work has shown that the -tocopherol transfer protein ( -TTP) can bind to vesicular or immo...
Peripheral membrane proteins can reversibly and specifically bind to biological membranes to carry o...
Phosphatidylinositol-transfer proteins (PITPs) regulate phosphoinositide signaling in eukaryotic cel...
Peripheral membrane proteins are structurally diverse proteins that are involved in fundamental cell...
The translocator protein (TSPO) is a 18kDa transmembrane protein, ubiquitously present in human mito...
Parallel advances in lipidomics and the structural biology of membrane proteins over the past decade...
SummaryInteractions of membrane proteins with lipid molecules are central to their stability and fun...
Understanding the energetics of peripheral protein-membrane interactions is important to many areas ...
In order to associate with the cytoplasmic leaflet of the plasma membrane, many cytosolic signalling...
Phosphatidylinositol transfer proteins (PITPs) are believed to be lipid transfer proteins due to the...
Vitamin E is an essential micronutrient. The primary function of this lipid-soluble antioxidant is t...
The cell membrane serves as a barrier between the interior and exterior of a living cell. Its main s...
Phosphatidylinositol transfer protein α (PITPα) selectively transports and promotes exchange of phos...