Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected by environmental factors, but has a strong heritable component. Despite recent large genome-wide association studies, few genetic risk factors for blood pressure have been identified. Epidemiological studies suggest associations between blood pressure and several diseases and traits, which may partly arise from a shared genetic basis (genetic pleiotropy). Using genome-wide association studies summary statistics and a genetic pleiotropy-informed conditional false discovery rate method, we systematically investigated genetic overlap between systolic blood pressure (SBP) and 12 comorbid traits and diseases. We found significant enrichment of sing...
Blood pressure (BP) is a heritable trait1 influenced by multiple biological pathways and is responsi...
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. W...
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. W...
Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected b...
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, i...
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, i...
High blood pressure (BP) remains the major heritable and modifiable risk factor for cardiovascular d...
Blood pressure (BP) is a heritable trait1 influenced by multiple biological pathways and is responsi...
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. W...
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. W...
Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected b...
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, i...
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, i...
High blood pressure (BP) remains the major heritable and modifiable risk factor for cardiovascular d...
Blood pressure (BP) is a heritable trait1 influenced by multiple biological pathways and is responsi...
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. W...
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. W...