Electrophysiological effects of prazosin during acute myocardial ischemia

Prazosin, 100 [mu]g/kg, had no effect on baseline refractoriness or intraventricular conduction in anesthetized dogs. During 1 h of coronary artery occlusion followed by reperfusion, prazosin significantly blunted the shortening of the ventricular effective refractory periods within ischemic myocardial region relative to vehicle-treated animals. Prazosin treatment also prevented the delayed conduction of paced ventricular complexes entering and exiting the ischemic zone. These effects may be associated with the blockade of [alpha]1-adrenoceptor activation during the acute phase of myocardial ischemia.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26081/1/0000157.pd