Despite improvements in detection and treatment of neonatal jaundice, there has been an apparent resurgence of bilirubin-induced brain damage. Unresolved issues concerning bilirubin-induced brain damage include the mechanisms by which bilirubin enters the brain and the molecular mechanisms by which bilirubin exerts its toxicity. These issues were the basis for the experimental studies performed in this thesis in pediatrics. In the first paper (paper I) we hypothesized that treatment with drugs known to inhibit the membrane transport protein phospho-glycoprotein (P-gp) would increase the entry of bilirubin into the brain of young adult Spraque-Dawley rats. In these in vivo experiments brain bilirubin content was examined after the iv inje...
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are the subgroup of the carcinoe...
Children operatively treated for hypoplastic left heart syndrome without anterograde selective cereb...
As the effects of global warming continue to spread throughout the world, another critical issue is ...
Melanoma is the most lethal form of skin cancer and accounts for the majority of skin cancer deaths....
More than half of patients admitted to burn centers for treatment have measurable alcohol levels in ...
Brain diseases including neurological disorders and tumors remain undertreated due to the challenge ...
The locus coeruleus (LC), the primary site of brain norepinephrine (NE), is a key anatomical brain r...
The locus coeruleus (LC), the primary site of brain norepinephrine (NE), is a key anatomical brain r...
Celiac disease (CD) is a chronic immune-mediated disease of the small intestine caused by the ingest...
Rhabdomyosarcoma is a family of rare juvenile cancers that express molecular factors implicated in m...
Specific structures and cell types in the organization of the liver are the key for its variant func...
Chapter One reviews the synthesis, properties and reactions of 2-methyleneaziridines, the subject of...
Background: Negative symptoms in schizophrenia are an important area of research due to their rel...
The overall objective of this project is to develop a simple and inexpensive process to separate car...
Children operatively treated for hypoplastic left heart syndrome without anterograde selective cereb...
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are the subgroup of the carcinoe...
Children operatively treated for hypoplastic left heart syndrome without anterograde selective cereb...
As the effects of global warming continue to spread throughout the world, another critical issue is ...
Melanoma is the most lethal form of skin cancer and accounts for the majority of skin cancer deaths....
More than half of patients admitted to burn centers for treatment have measurable alcohol levels in ...
Brain diseases including neurological disorders and tumors remain undertreated due to the challenge ...
The locus coeruleus (LC), the primary site of brain norepinephrine (NE), is a key anatomical brain r...
The locus coeruleus (LC), the primary site of brain norepinephrine (NE), is a key anatomical brain r...
Celiac disease (CD) is a chronic immune-mediated disease of the small intestine caused by the ingest...
Rhabdomyosarcoma is a family of rare juvenile cancers that express molecular factors implicated in m...
Specific structures and cell types in the organization of the liver are the key for its variant func...
Chapter One reviews the synthesis, properties and reactions of 2-methyleneaziridines, the subject of...
Background: Negative symptoms in schizophrenia are an important area of research due to their rel...
The overall objective of this project is to develop a simple and inexpensive process to separate car...
Children operatively treated for hypoplastic left heart syndrome without anterograde selective cereb...
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are the subgroup of the carcinoe...
Children operatively treated for hypoplastic left heart syndrome without anterograde selective cereb...
As the effects of global warming continue to spread throughout the world, another critical issue is ...