A catalytic reduction of the nitrile portion of the trimethylsilyl cyanohydrin to a primary amine has produced an situ annulation to generate the 3,4,5-trihydro-1,3-diazepin-5-ol ring. This ring substructure has demonstrated important biological significant.3Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25459/1/0000909.pd
© 2015 Elsevier Ltd. All rights reserved. Functionalised azepane and oxepane scaffolds were prepared...
The phenolic -diketones I prepared by modied Baker-Venkataraman rearrangement were converted to the ...
Synthetic efforts aimed at preparing potential adenosine deaminase inhibitors are presented. The wor...
Abstract: A catalytic reduction of the nitrile portion of the trimethylsilyl cyanohydrin 7 to a prim...
A reduction of the nitrile group of 5‐amino‐4‐cyano‐1‐methylpyrazole ( 3 ) has provided the very ver...
While the benzodiazepine drug class has been amongst the most prescribed medication globally since i...
Triply fused 1,3-diazepine derivatives have been obtained by acidic reduction of rotationally locked...
The work described in this dissertation is a continuation of decades of research conducted in this l...
While the benzodiazepine drug class has been amongst the most prescribed medication globally since i...
An easy access has been demonstrated for seven membered diazepines and a six membered quinoxaline. T...
To date, compound collections based on ‘privileged structures’ play a key role in the hit discovery ...
A study of the reactivity of a non-stabilised azomethine ylide, derived from N-(methoxymethyl)-N-(tr...
A number of possible synthetic routes to monocyclic, fully unsaturated 1,3-diazepines are reported. ...
1,2-Diazetidin-3-ones are readily accessible, small ring scaffolds that upon functionalization have ...
Cytidine deaminase (CDA) catalyzes the deamination of cytidine via a hydrated transition-state inter...
© 2015 Elsevier Ltd. All rights reserved. Functionalised azepane and oxepane scaffolds were prepared...
The phenolic -diketones I prepared by modied Baker-Venkataraman rearrangement were converted to the ...
Synthetic efforts aimed at preparing potential adenosine deaminase inhibitors are presented. The wor...
Abstract: A catalytic reduction of the nitrile portion of the trimethylsilyl cyanohydrin 7 to a prim...
A reduction of the nitrile group of 5‐amino‐4‐cyano‐1‐methylpyrazole ( 3 ) has provided the very ver...
While the benzodiazepine drug class has been amongst the most prescribed medication globally since i...
Triply fused 1,3-diazepine derivatives have been obtained by acidic reduction of rotationally locked...
The work described in this dissertation is a continuation of decades of research conducted in this l...
While the benzodiazepine drug class has been amongst the most prescribed medication globally since i...
An easy access has been demonstrated for seven membered diazepines and a six membered quinoxaline. T...
To date, compound collections based on ‘privileged structures’ play a key role in the hit discovery ...
A study of the reactivity of a non-stabilised azomethine ylide, derived from N-(methoxymethyl)-N-(tr...
A number of possible synthetic routes to monocyclic, fully unsaturated 1,3-diazepines are reported. ...
1,2-Diazetidin-3-ones are readily accessible, small ring scaffolds that upon functionalization have ...
Cytidine deaminase (CDA) catalyzes the deamination of cytidine via a hydrated transition-state inter...
© 2015 Elsevier Ltd. All rights reserved. Functionalised azepane and oxepane scaffolds were prepared...
The phenolic -diketones I prepared by modied Baker-Venkataraman rearrangement were converted to the ...
Synthetic efforts aimed at preparing potential adenosine deaminase inhibitors are presented. The wor...
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