An inherited deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) is associated with an autosomal recessive form of severe combined immunodeficiency disease. Affected patients exhibit markedly reduced or absent adenosine deaminating activity in various tissues. In this study we have demonstrated the presence of a low level aminohydrolase activity in 11 different normal and adenosine deaminase-deficient lymphoblast cell lines which is apparently distinct from normal adenosine deaminase. Based on enzymatic, physical and immunoreactive properties, this lymphoblast aminohydrolase does not appear to be related to adenosine deaminase and is most likely coded for by a different gene locus. In future investigations designed to c...
Deficiency of the enzyme adenosine deaminase (ADA) results in severe lymphopenia in humans. Mice wit...
The biochemical mechanisms whereby an inherited deficiency of adenosine de-aminase (ADA; EC 3.5.4.4)...
Abstract Adenosine deaminase (ADA) deficiency leads to an accumulation of toxic purine degradation b...
A deficiency of the enzyme adenosine deamin-ase is associated with an autosomal recessive form of se...
A deficiency of the enzyme adenosine deaminase is associated with an autosomal recessive form of sev...
345-356Adenosine deaminase deficiency accounts for ~15-20% of severe combined immunodeficiency in h...
aminase (ADA) usually causes profound lymphopenia with severe combined immunodeficiency disease. Cel...
The nature of the association of adenosine deaminase deficiency and severe combined immunodeficiency...
adenosine deaminase (ADA) results in a syndrome of severe combined immunodeficiency (SCID). Children...
High levels of adenosine deaminase (ADA) activity have been associated with normal T cell differenti...
SummaryAdenosine deaminase (ADA) deficiency causes lymphopenia and immunodeficiency due to toxic eff...
Adenosine deaminase is an enzyme that actively participates in the metabolism of the adenine nucleot...
Adenine phosphoribosyltransferase (APRT) was characterized with respect to specific activity and imm...
Mice homozygous for the mutation wasted (wst/wst) have been postulated to be a model for the form of...
We determined the activity of adenosine deaminase in normal lymphocytes from peripheral blood, leuke...
Deficiency of the enzyme adenosine deaminase (ADA) results in severe lymphopenia in humans. Mice wit...
The biochemical mechanisms whereby an inherited deficiency of adenosine de-aminase (ADA; EC 3.5.4.4)...
Abstract Adenosine deaminase (ADA) deficiency leads to an accumulation of toxic purine degradation b...
A deficiency of the enzyme adenosine deamin-ase is associated with an autosomal recessive form of se...
A deficiency of the enzyme adenosine deaminase is associated with an autosomal recessive form of sev...
345-356Adenosine deaminase deficiency accounts for ~15-20% of severe combined immunodeficiency in h...
aminase (ADA) usually causes profound lymphopenia with severe combined immunodeficiency disease. Cel...
The nature of the association of adenosine deaminase deficiency and severe combined immunodeficiency...
adenosine deaminase (ADA) results in a syndrome of severe combined immunodeficiency (SCID). Children...
High levels of adenosine deaminase (ADA) activity have been associated with normal T cell differenti...
SummaryAdenosine deaminase (ADA) deficiency causes lymphopenia and immunodeficiency due to toxic eff...
Adenosine deaminase is an enzyme that actively participates in the metabolism of the adenine nucleot...
Adenine phosphoribosyltransferase (APRT) was characterized with respect to specific activity and imm...
Mice homozygous for the mutation wasted (wst/wst) have been postulated to be a model for the form of...
We determined the activity of adenosine deaminase in normal lymphocytes from peripheral blood, leuke...
Deficiency of the enzyme adenosine deaminase (ADA) results in severe lymphopenia in humans. Mice wit...
The biochemical mechanisms whereby an inherited deficiency of adenosine de-aminase (ADA; EC 3.5.4.4)...
Abstract Adenosine deaminase (ADA) deficiency leads to an accumulation of toxic purine degradation b...