Cold-adapted variants of influenza virus A : I. Comparison of the genetic properties of ts mutants and five cold-adapted variants of influenza virus A

The genetic properties of seven cold-adapted variants of influenza virus A were compared with those of nine 5-fluorouracil (5-FU)-induced ts mutants. The 5-FU mutants had previously been placed into seven complementation-recombination groups; five of the seven cold-adapted variants also had the ts phenotype, and all five were shown to share the group 1 lesion. Three of the cold variants also had additional ts lesions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23047/1/0000619.pd