Administration of chloramphenicol early in CCl4 intoxication prevents lipid peroxidation of endoplasmic reticulum membranes. Conversely, a sulfamoyl analog, Tevenel, was ineffective in preventing the lipoperoxidative process. Likewise, in an in vitro microsomal system chloramphenicol inhibited a lipid peroxidation process and Tevenel did not. However, both compounds bind to cytochrome P-450. Chloramphenicol did not maintain cytochrome P-450 levels after CCl4 administration nor did it depress cytochrome P-450 levels in untreated animals. The data obtained indicate that chloramphenicol may prevent lipid peroxidation either by inhibiting CCl4 metabolism or by acting as a free radical sequestering agent.Peer Reviewedhttp://deepblue.lib.umich.ed...
The protective action of thymol (paramethyl-isopropyl-phenol) was investigated against carbon tetrac...
Generation of reactive oxygen species beyond the antioxidant capacity of biological system has been ...
n-Hexane1 Treatment of rats with chioramphenicol causes a dose-depend-em and regioselective inhibfti...
The damage induced in the mitochondria of rat liver during intoxication by carbon tetrachloride is p...
The cytochrome P-450 dependent monooxygenase system plays a key role in the bioactivation and detoxi...
1. The molecular mechanism and the reactive species involved in the inactivation of microsomal cytoc...
International audienceAlthough carbon tetrachloride (CCl(4))-induced acute and chronic hepatotoxicit...
The metabolism of carbon tetrachloride has been investigated in liver microsomes and in reconstitute...
microsomes and reconstituted monooxygenase systems and its relationship to lipid peroxidation. Mol. ...
AbstractToxic effects of chloramphenicol, an antibiotic inhibitor of mitochondrial protein synthesis...
AbstractTreatment of rats with ethanol or rabbits with either imidazole or pyrazole, agents known to...
Carbonyl compounds released during the NADPH-Fe dependent peroxidation of liver microsomal lipids an...
A single dose of CCl4 when administered to a rat produces centrilobular necrosis and fatty degenerat...
The protective action of thymol (paramethyl-isopropyl-phenol) was investigated against carbon tetrac...
The protective action of thymol (paramethyl-isopropyl-phenol) was investigated against carbon tetrac...
Generation of reactive oxygen species beyond the antioxidant capacity of biological system has been ...
n-Hexane1 Treatment of rats with chioramphenicol causes a dose-depend-em and regioselective inhibfti...
The damage induced in the mitochondria of rat liver during intoxication by carbon tetrachloride is p...
The cytochrome P-450 dependent monooxygenase system plays a key role in the bioactivation and detoxi...
1. The molecular mechanism and the reactive species involved in the inactivation of microsomal cytoc...
International audienceAlthough carbon tetrachloride (CCl(4))-induced acute and chronic hepatotoxicit...
The metabolism of carbon tetrachloride has been investigated in liver microsomes and in reconstitute...
microsomes and reconstituted monooxygenase systems and its relationship to lipid peroxidation. Mol. ...
AbstractToxic effects of chloramphenicol, an antibiotic inhibitor of mitochondrial protein synthesis...
AbstractTreatment of rats with ethanol or rabbits with either imidazole or pyrazole, agents known to...
Carbonyl compounds released during the NADPH-Fe dependent peroxidation of liver microsomal lipids an...
A single dose of CCl4 when administered to a rat produces centrilobular necrosis and fatty degenerat...
The protective action of thymol (paramethyl-isopropyl-phenol) was investigated against carbon tetrac...
The protective action of thymol (paramethyl-isopropyl-phenol) was investigated against carbon tetrac...
Generation of reactive oxygen species beyond the antioxidant capacity of biological system has been ...
n-Hexane1 Treatment of rats with chioramphenicol causes a dose-depend-em and regioselective inhibfti...