The glucocerebrosidase of human placenta was studied with various potential inhibitors. Several compounds that resemble the lipoidal product of enzyme action, ceramide, proved to be excellent inhibitors, acting by mixed modes (primarily noncompetitively). These were N-decyl--erythro-3-phenyl-2-amino-l, 3-propanediol and several p-substituted derivatives. These compounds were also highly effective in rat spleen toward glucocerebroside and p-nitrophenyl [beta]-glucoside as substrates. The compounds were inactive toward the analogous enzyme, galactocerebrosidase of rat brain, and were slightly stimulatory toward the rat brain enzyme which makes galactocerebroside. Longer and shorter N-alkyl groups proved to be less effective. Decanoic acid ami...
A method is described for the preparation of a [beta]-galactosidase which acts on the brain lipid, c...
A description is given for the preparation of some glucosides related to cerebrosides. Optically act...
Glucosylceramide metabolism and the enzymes involved have attracted significant interest in medicina...
In a search for potent inhibitors of glucocerebroside biosynthesis, we synthesized aromatic analogs ...
In a search for potent inhibitors of glucocerebroside biosynthesis, we synthesized aromatic analogs ...
Brain homogenates from young rats were assayed for their ability to synthesize cerebrosides from rad...
Abstract-Brain homogenates from young rats were assayed for their ability to synthesize cerebrosides...
1. 1. The brain enzyme which forms galactosyl ceramide ("cerebroside") from UDPGal and hydroxy ceram...
A preparation of galactosyl ceramide galactosidase from rat brain has been tested with potential inh...
In order to increase the sensitivity of the assay for ceramide: UDPGlc glucosyltransferase, the enzy...
Ceramide glucosyltransferase (CGT) is a key enzyme in glycosphingolipid (GSL) biosynthesis in eukary...
A series of lipidated guanidino and urea derivatives of 1,5-dideoxy-1,5-imino-d-xylitol were prepare...
Gangliosides stimulate the hydrolysis of glucosylceramide (GlcCer), their precursor, and therefore m...
Analogs of ceramide which inhibit galactocerebrosidase also demyelinate or inhibit myelination in or...
The nature of the stimulatory action of the protein `coglucosidase' on gluco-cerebrosidase was inves...
A method is described for the preparation of a [beta]-galactosidase which acts on the brain lipid, c...
A description is given for the preparation of some glucosides related to cerebrosides. Optically act...
Glucosylceramide metabolism and the enzymes involved have attracted significant interest in medicina...
In a search for potent inhibitors of glucocerebroside biosynthesis, we synthesized aromatic analogs ...
In a search for potent inhibitors of glucocerebroside biosynthesis, we synthesized aromatic analogs ...
Brain homogenates from young rats were assayed for their ability to synthesize cerebrosides from rad...
Abstract-Brain homogenates from young rats were assayed for their ability to synthesize cerebrosides...
1. 1. The brain enzyme which forms galactosyl ceramide ("cerebroside") from UDPGal and hydroxy ceram...
A preparation of galactosyl ceramide galactosidase from rat brain has been tested with potential inh...
In order to increase the sensitivity of the assay for ceramide: UDPGlc glucosyltransferase, the enzy...
Ceramide glucosyltransferase (CGT) is a key enzyme in glycosphingolipid (GSL) biosynthesis in eukary...
A series of lipidated guanidino and urea derivatives of 1,5-dideoxy-1,5-imino-d-xylitol were prepare...
Gangliosides stimulate the hydrolysis of glucosylceramide (GlcCer), their precursor, and therefore m...
Analogs of ceramide which inhibit galactocerebrosidase also demyelinate or inhibit myelination in or...
The nature of the stimulatory action of the protein `coglucosidase' on gluco-cerebrosidase was inves...
A method is described for the preparation of a [beta]-galactosidase which acts on the brain lipid, c...
A description is given for the preparation of some glucosides related to cerebrosides. Optically act...
Glucosylceramide metabolism and the enzymes involved have attracted significant interest in medicina...