A physical model for the simultaneous membrane transport and metabolism of drugs

A simple model for the simultaneous passive membrane transport and bioconversion of a drug, which may be a weak electrolyte or a neutral molecule, is mathematically described. It includes an aqueous diffusion layer and an operational aqueous pore pathway. The applicability of the model is shown for the in situ rat intestinal transport of prostaglandin F2a.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/21678/1/0000066.pd