Identification of genes regulated by Wnt/beta-catenin pathway and involved in apoptosis via microarray analysis.
- Huang, Moli
- Wang, Yihua
- Sun, Daochun
- Zhu, Hongxia
- Yin, Yanbing
- Zhang, Wei
- Yang, Shangbin
- Quan, Lanping
- Bai, Jinfeng
- Wang, Shengqi
- Chen, Quan
- Li, Songgang
- Xu, Ningzhi
Publication date
September 2006
DOI Publisher
Springer Science and Business Media LLCAbstract
Coupling RNAi knockdown with microarray and RT-PCR analyses proves to be a versatile strategy for identifying genes regulated by Wnt/beta-catenin pathway and for a better understanding the role of this pathway in apoptosis. Some of the identified beta-catenin/TCF directed or indirected target genes may represent excellent targets to limit tumor growth
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