Human embryonic stem cells (hESCs) have the capacity to differentiate into all cell types and thus have great potential for regenerative medicine. hESCs cultured at low oxygen tensions are more pluripotent and display an increased glycolytic rate but how this is regulated is unknown. This study therefore aimed to investigate the regulation of glucose metabolism in hESCs and whether this might impact OCT4 expression. In contrast to the glucose transporter GLUT1, GLUT3 was regulated by environmental oxygen and localised to hESC membranes. Silencing GLUT3 caused a reduction in glucose uptake and lactate production as well as OCT4 expression. GLUT3 and OCT4 expression were correlated suggesting that hESC self-renewal is regulated by the rate of...
Metabolism has been shown to alter cell fate in human pluripotent stem cells (hPSC). However, curren...
Human pluripotent stem cells have the ability to generate all cell types present in the adult organi...
As human embryonic stem cells (hESCs) steadily progress towards regenerative medicine applications t...
Energy metabolism is intrinsic to cell viability but surprisingly has been little studied in human e...
<div><p>Energy metabolism is intrinsic to cell viability but surprisingly has been little studied in...
Summary: Glycolysis and hypoxia are key regulators of human embryonic stem cell (hESC) self-renewal,...
Human embryonic stem cells (hESCs) hold potential in the field of tissue engineering to treat a wide...
Oxygen is a powerful regulator of cell function and embryonic development. It has previously been de...
Glycolysis and hypoxia are key regulators of human embryonic stem cell (hESC) self-renewal, but how ...
SummaryThe molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in ...
The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human e...
As human embryonic stem cells (hESCs) steadily progress towards regenerative medicine applications t...
BACKGROUND: Human pluripotent stem cells have the ability to generate all cell types present in the ...
Human embryonic stem (hES) cells derived from the inner cell mass of the blastocyst propagate by sel...
Background/aims: human embryonic stem cells (hESCs) are a potential source of cells for treatment of...
Metabolism has been shown to alter cell fate in human pluripotent stem cells (hPSC). However, curren...
Human pluripotent stem cells have the ability to generate all cell types present in the adult organi...
As human embryonic stem cells (hESCs) steadily progress towards regenerative medicine applications t...
Energy metabolism is intrinsic to cell viability but surprisingly has been little studied in human e...
<div><p>Energy metabolism is intrinsic to cell viability but surprisingly has been little studied in...
Summary: Glycolysis and hypoxia are key regulators of human embryonic stem cell (hESC) self-renewal,...
Human embryonic stem cells (hESCs) hold potential in the field of tissue engineering to treat a wide...
Oxygen is a powerful regulator of cell function and embryonic development. It has previously been de...
Glycolysis and hypoxia are key regulators of human embryonic stem cell (hESC) self-renewal, but how ...
SummaryThe molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in ...
The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human e...
As human embryonic stem cells (hESCs) steadily progress towards regenerative medicine applications t...
BACKGROUND: Human pluripotent stem cells have the ability to generate all cell types present in the ...
Human embryonic stem (hES) cells derived from the inner cell mass of the blastocyst propagate by sel...
Background/aims: human embryonic stem cells (hESCs) are a potential source of cells for treatment of...
Metabolism has been shown to alter cell fate in human pluripotent stem cells (hPSC). However, curren...
Human pluripotent stem cells have the ability to generate all cell types present in the adult organi...
As human embryonic stem cells (hESCs) steadily progress towards regenerative medicine applications t...