BACKGROUND: Genes upregulated within the tumour microenvironment represent potential targets for rational drug design. Most studies to date concentrate on the effects of hypoxia, although it is likely many genes are regulated by a more physiological combination of factors. MATERIALS & METHODS: Cells under conditions analogous to the normal and tumour microenvironments were isolated from the plateau-phase system and multicellular spheroids. Gene expression was analysed by differential display and confirmed by Northern blot or semiquantitative RT-PCR. RESULTS: p21-activated kinase (PAK1), a calmodulin-related mRNA, cytochrome oxidase subunit I and an H3.3 histone were upregulated within the in vitro tumour microenvironment, the last 3 with...
Hypoxia is a common characteristic of many solid tumors that has been associated with tumor aggressi...
grantor: University of TorontoMetastasis is the process by which individual tumor cells es...
Hypoxia is one of the most important features of the tumor microenvironment, exerting an adverse eff...
BACKGROUND: Genes upregulated within the tumour microenvironment represent potential targets for rat...
Background The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a m...
Solid tumours can contain areas of poor oxygenation and nutrient status, and tumour cells in these ...
<div><p>Tumor microenvironments present significant barriers to anti-tumor agents. Molecules involve...
Tumor microenvironments present significant barriers to anti-tumor agents. Molecules involved in mul...
Tumor permeability is a critical determinant of drug delivery and sensitivity, but systematic method...
International audienceTumour microenvironment determines the fate of treatments. Reconstitution of t...
BACKGROUND: The presence of hypoxic regions within solid tumors is associated with a more malignant ...
Abstract Under hypoxic conditions, tumor cells undergo a series of adaptations that promote evolutio...
Contains fulltext : 154649.pdf (publisher's version ) (Closed access)There is an i...
Tumor cell lines are relied upon extensively for cancer investigations, yet cultured cells in an in ...
Cancer cells in hypoxic areas of solid tumors are to a large extent protected against the action of ...
Hypoxia is a common characteristic of many solid tumors that has been associated with tumor aggressi...
grantor: University of TorontoMetastasis is the process by which individual tumor cells es...
Hypoxia is one of the most important features of the tumor microenvironment, exerting an adverse eff...
BACKGROUND: Genes upregulated within the tumour microenvironment represent potential targets for rat...
Background The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a m...
Solid tumours can contain areas of poor oxygenation and nutrient status, and tumour cells in these ...
<div><p>Tumor microenvironments present significant barriers to anti-tumor agents. Molecules involve...
Tumor microenvironments present significant barriers to anti-tumor agents. Molecules involved in mul...
Tumor permeability is a critical determinant of drug delivery and sensitivity, but systematic method...
International audienceTumour microenvironment determines the fate of treatments. Reconstitution of t...
BACKGROUND: The presence of hypoxic regions within solid tumors is associated with a more malignant ...
Abstract Under hypoxic conditions, tumor cells undergo a series of adaptations that promote evolutio...
Contains fulltext : 154649.pdf (publisher's version ) (Closed access)There is an i...
Tumor cell lines are relied upon extensively for cancer investigations, yet cultured cells in an in ...
Cancer cells in hypoxic areas of solid tumors are to a large extent protected against the action of ...
Hypoxia is a common characteristic of many solid tumors that has been associated with tumor aggressi...
grantor: University of TorontoMetastasis is the process by which individual tumor cells es...
Hypoxia is one of the most important features of the tumor microenvironment, exerting an adverse eff...