This is the first report in the Australian Burden of Disease Study series. It provides estimates of fatal burden for 2010 showing the contribution of each disease group by age and sex. The three leading disease groups were Cancer (35%), Cardiovascular diseases (23%) and Injuries (13%), and these contributed more than 70% of total fatal burden. Summary Burden of disease analysis is a way to simultaneously count and compare the fatal and non-fatal impacts of different diseases and injuries. It uses information from multiple data sources to quantify the impact on a population of illness and premature death from all diseases and injuries. It uses a summary measure, the DALY (disability-adjusted life year), to describe the resulting heal...