T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens to provide protection against infection. We found that in both naive T cells and effector T cells, the tyrosine phosphatase PTPN22 limited signaling via the T cell antigen receptor (TCR) by weak agonists and self antigens while not impeding responses to strong agonist antigens. T cells lacking PTPN22 showed enhanced formation of conjugates with antigen-presenting cells pulsed with weak peptides, which led to activation of the T cells and their production of inflammatory cytokines. This effect was exacerbated under conditions of lymphopenia, with the formation of potent memory T cells in the absence of PTPN22. Our data address how loss-of-funct...
<div><p>The PTPN22<sup>R620W</sup> single nucleotide polymorphism increases the risk of developing m...
The PTPN22R620W single nucleotide polymorphism increases the risk of developing multiple autoimmune ...
A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for t...
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens t...
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens t...
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens t...
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens t...
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens t...
The non-receptor tyrosine phospha-tase PTPN22 has a vital function in inhibiting antigen-receptor si...
The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase nonreceptor type 22) plays a key ro...
The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase nonreceptor type 22) plays a key ro...
The non-receptor tyrosine phosphatase PTPN22 has a vital function in inhibiting antigen-receptor sig...
Many autoimmune diseases exhibit familial aggregation, indicating that they have genetic determinant...
The tyrosine phosphatase PTPN22 regulates T cell receptor signaling. In this issue of Immunity, Wang...
International audienceLymphopenic insult has been shown to precipitate the initiation of autoimmune ...
<div><p>The PTPN22<sup>R620W</sup> single nucleotide polymorphism increases the risk of developing m...
The PTPN22R620W single nucleotide polymorphism increases the risk of developing multiple autoimmune ...
A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for t...
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens t...
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens t...
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens t...
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens t...
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens t...
The non-receptor tyrosine phospha-tase PTPN22 has a vital function in inhibiting antigen-receptor si...
The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase nonreceptor type 22) plays a key ro...
The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase nonreceptor type 22) plays a key ro...
The non-receptor tyrosine phosphatase PTPN22 has a vital function in inhibiting antigen-receptor sig...
Many autoimmune diseases exhibit familial aggregation, indicating that they have genetic determinant...
The tyrosine phosphatase PTPN22 regulates T cell receptor signaling. In this issue of Immunity, Wang...
International audienceLymphopenic insult has been shown to precipitate the initiation of autoimmune ...
<div><p>The PTPN22<sup>R620W</sup> single nucleotide polymorphism increases the risk of developing m...
The PTPN22R620W single nucleotide polymorphism increases the risk of developing multiple autoimmune ...
A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for t...