Genome-wide association studies have previously identified variants in SLC30A8, encoding the zinc transporter ZnT8, associated with diabetes risk. A rare variant association study has now established the direction of effect, surprisingly showing that loss-of-function mutations in SLC30A8 are protective against diabetes.</p
UnrestrictedZinc is an essential trace element in living organisms, and zinc content in pancreatic β...
Zinc is a critical element for insulin storage in the secretory granules of pancreatic beta cells. T...
Zinc levels in pancreatic islets are amongst the highest in the body and reduction in its levels in ...
Genome-wide association studies have previously identified variants in SLC30A8, encoding the zinc tr...
Context/Objective: The variant rs13266634 in SLC30A8, encoding a beta-cell-specific zinc transporter...
Loss-of-function mutations protective against human disease provide in vivo validation of therapeuti...
Loss-of-function mutations protective against human disease provide in vivo validation of therapeuti...
Loss-of-function mutations protective against human disease provide in vivo validation of therapeuti...
Zinc level in the body is finely regulated to maintain cellular function. Dysregulation of zinc meta...
Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diabetes. Apart from...
A rare loss-of-function variant p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8) enriched...
Aims/hypothesis Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diab...
BACKGROUND: The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the p...
Type 2 diabetes mellitus results from the interaction of environmental factors with a combination of...
Type 2 diabetes mellitus (T2DM) is one of the threatening disorders in the world. It affects people ...
UnrestrictedZinc is an essential trace element in living organisms, and zinc content in pancreatic β...
Zinc is a critical element for insulin storage in the secretory granules of pancreatic beta cells. T...
Zinc levels in pancreatic islets are amongst the highest in the body and reduction in its levels in ...
Genome-wide association studies have previously identified variants in SLC30A8, encoding the zinc tr...
Context/Objective: The variant rs13266634 in SLC30A8, encoding a beta-cell-specific zinc transporter...
Loss-of-function mutations protective against human disease provide in vivo validation of therapeuti...
Loss-of-function mutations protective against human disease provide in vivo validation of therapeuti...
Loss-of-function mutations protective against human disease provide in vivo validation of therapeuti...
Zinc level in the body is finely regulated to maintain cellular function. Dysregulation of zinc meta...
Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diabetes. Apart from...
A rare loss-of-function variant p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8) enriched...
Aims/hypothesis Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diab...
BACKGROUND: The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the p...
Type 2 diabetes mellitus results from the interaction of environmental factors with a combination of...
Type 2 diabetes mellitus (T2DM) is one of the threatening disorders in the world. It affects people ...
UnrestrictedZinc is an essential trace element in living organisms, and zinc content in pancreatic β...
Zinc is a critical element for insulin storage in the secretory granules of pancreatic beta cells. T...
Zinc levels in pancreatic islets are amongst the highest in the body and reduction in its levels in ...
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