Context: Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cyclin D1 (CCND1) genes, occur in Objective: To identify genetic abnormalities in nonhereditary parathyroid adenomas by whole-exome sequence analysis.Design: Whole-exome sequence analysis was performed on parathyroid adenomas and leukocyte DNA samples from 16 postmenopausal women without a family history of parathyroid tumors or MEN1 and in whom primary hyperparathyroidism due to single-gland disease was cured by surgery. Somatic variants confirmed in this discovery set were assessed in 24 other parathyroid adenomas.Results: Over 90% of targeted exons were captured and represented by more than 10 base reads. Analysis identified 212 somatic varian...
Objectives: Somatic deletion of chromosome 11q13 is the most frequent genetic aberration in para-thy...
Purpose: Familial isolated hyperparathyroidism (FIHP) is a rare inherited disease accounting for 1% ...
Endocrine tumors arise from endocrine glands. Most endocrine tumors are benign but malignant variant...
Context: Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cycl...
CONTEXT: Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cycl...
Context: The tumorigenic role of genetic abnormalities in sporadic pituitary nonfunctioning adenomas...
CONTEXT: The tumorigenic role of genetic abnormalities in sporadic pituitary nonfunctioning adenomas...
The molecular pathogenesis of parathyroid adenomas has yet to be fully elucidated with only two gene...
Abstract Background Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant her...
Context: Typical nonfamilial (sporadic) parathyroid adenomas are common endocrine tumors for which n...
Context: Cell division cycle 73 (CDC73), encoding the protein parafibromin, is the most prevalent mu...
Parathyroid carcinoma (PC) is an extremely rare malignancy lacking effective therapeutic interventio...
Abstract We report nine mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in sporadi...
Objectives: Somatic deletion of chromosome 11q13 is the most frequent genetic aberration in para-thy...
Purpose: Familial isolated hyperparathyroidism (FIHP) is a rare inherited disease accounting for 1% ...
Endocrine tumors arise from endocrine glands. Most endocrine tumors are benign but malignant variant...
Context: Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cycl...
CONTEXT: Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cycl...
Context: The tumorigenic role of genetic abnormalities in sporadic pituitary nonfunctioning adenomas...
CONTEXT: The tumorigenic role of genetic abnormalities in sporadic pituitary nonfunctioning adenomas...
The molecular pathogenesis of parathyroid adenomas has yet to be fully elucidated with only two gene...
Abstract Background Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant her...
Context: Typical nonfamilial (sporadic) parathyroid adenomas are common endocrine tumors for which n...
Context: Cell division cycle 73 (CDC73), encoding the protein parafibromin, is the most prevalent mu...
Parathyroid carcinoma (PC) is an extremely rare malignancy lacking effective therapeutic interventio...
Abstract We report nine mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in sporadi...
Objectives: Somatic deletion of chromosome 11q13 is the most frequent genetic aberration in para-thy...
Purpose: Familial isolated hyperparathyroidism (FIHP) is a rare inherited disease accounting for 1% ...
Endocrine tumors arise from endocrine glands. Most endocrine tumors are benign but malignant variant...