Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome
- Sengupta, Sugopa
- van Deursen, Frederick
- de Piccoli, Giacomo
- Labib, Karim
DOIAbstract
The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation
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