Visceral leishmaniasis is a neglected tropical disease with significant health impact. Current treatments are poor and there is an urgent need to develop new drugs. Primary screening assays used for drug discovery campaigns have typically used free-living forms of the Leishmania parasite to allow for high-throughput screening. Such screens do not necessarily reflect the physiological situation as the disease-causing stage of the parasite resides inside human host cells. Assessing drug sensitivity of intracellular parasites on scale has recently become feasible with the advent of high-content screening methods. Here we present a 384 well microscopy-based intramacrophage Leishmania donovani assay and compare it to an axenic amastigote system....
We have refined a medium-throughput assay to screen hit compounds for activity against N-myristoylat...
Leishmania parasites cause a set of neglected tropical diseases with considerable public health impa...
Drugs currently available for leishmaniasis treatment often show parasite resistance, highly toxic s...
Visceral leishmaniasis is a neglected tropical disease with significant health impact. Current treat...
Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arse...
Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arse...
<div><p>Leishmaniasis is a tropical disease threatening 350 million people from endemic regions. The...
Leishmaniasis is a tropical disease threatening 350 million people from endemic regions. The availab...
Leishmaniasis is a tropical disease threatening 350 million people from endemic regions. The availab...
Visceral leishmaniasis is an important parasitic disease of the developing world with a lim-ited ars...
International audienceThe limited success of recent phenotypic anti-leishmanial drug screening campa...
Critical to the search for new anti-leishmanial drugs is the availability of high-throughput screeni...
The protozoan parasite Leishmania donovani is the causative agent of visceral leishmaniasis, a disea...
<div><p>Background/Objectives</p><p>Human leishmaniases are parasitic diseases causing severe morbid...
The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an...
We have refined a medium-throughput assay to screen hit compounds for activity against N-myristoylat...
Leishmania parasites cause a set of neglected tropical diseases with considerable public health impa...
Drugs currently available for leishmaniasis treatment often show parasite resistance, highly toxic s...
Visceral leishmaniasis is a neglected tropical disease with significant health impact. Current treat...
Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arse...
Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arse...
<div><p>Leishmaniasis is a tropical disease threatening 350 million people from endemic regions. The...
Leishmaniasis is a tropical disease threatening 350 million people from endemic regions. The availab...
Leishmaniasis is a tropical disease threatening 350 million people from endemic regions. The availab...
Visceral leishmaniasis is an important parasitic disease of the developing world with a lim-ited ars...
International audienceThe limited success of recent phenotypic anti-leishmanial drug screening campa...
Critical to the search for new anti-leishmanial drugs is the availability of high-throughput screeni...
The protozoan parasite Leishmania donovani is the causative agent of visceral leishmaniasis, a disea...
<div><p>Background/Objectives</p><p>Human leishmaniases are parasitic diseases causing severe morbid...
The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an...
We have refined a medium-throughput assay to screen hit compounds for activity against N-myristoylat...
Leishmania parasites cause a set of neglected tropical diseases with considerable public health impa...
Drugs currently available for leishmaniasis treatment often show parasite resistance, highly toxic s...