Neutrophil entry into the lung tissues is a key step in host defense to bacterial and yeast infections, but if uncontrolled can lead to severe tissue damage. Here, we demonstrate for the first time that sialic acid binding Ig-like lectin E (siglec-E) functions to selectively regulate early neutrophil recruitment into the lung. In a model of acute lung inflammation induced by aerosolized lipopolysaccharide, siglec-E-deficient mice exhibited exaggerated neutrophil recruitment that was reversed by blockade of the ß2 integrin, CD11b. Siglec-E suppressed CD11b "outside-in" signaling, because siglec-E-deficient neutrophils plated on the CD11b ligand fibrinogen showed exaggerated phosphorylation of Syk and p38 mitogen-activated protein kinase. Sia...
Both pathogen- and tissue damage-associated molecular patterns induce inflammation through toll-like...
SummaryAtherosclerosis is initiated and sustained by hypercholesterolemia, which results in the gene...
Background: Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that...
Neutrophil entry into the lung tissues is a key step in host defense to bacterial and yeast infectio...
Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells. It has recently ...
Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune...
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a group of cell surface transmembrane ...
ABSTRACT Cell surface expression of sialic acid has been reported to decrease during immune cell act...
ABSTRACT Cell surface expression of sialic acid has been reported to decrease during immune cell act...
Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is a trans-membrane receptor carrying im...
Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is a trans-membrane receptor carrying im...
<div><p>Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is a trans-membrane receptor car...
Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is a trans-membrane receptor carryng imm...
International audienceInteractions between endothelial selectins and the leukocyte counter-receptor ...
Background: Sialic acid-binding Ig-like lectin 9 (Siglec-9) is constitutively expressed on neutrophi...
Both pathogen- and tissue damage-associated molecular patterns induce inflammation through toll-like...
SummaryAtherosclerosis is initiated and sustained by hypercholesterolemia, which results in the gene...
Background: Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that...
Neutrophil entry into the lung tissues is a key step in host defense to bacterial and yeast infectio...
Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells. It has recently ...
Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune...
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a group of cell surface transmembrane ...
ABSTRACT Cell surface expression of sialic acid has been reported to decrease during immune cell act...
ABSTRACT Cell surface expression of sialic acid has been reported to decrease during immune cell act...
Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is a trans-membrane receptor carrying im...
Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is a trans-membrane receptor carrying im...
<div><p>Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is a trans-membrane receptor car...
Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is a trans-membrane receptor carryng imm...
International audienceInteractions between endothelial selectins and the leukocyte counter-receptor ...
Background: Sialic acid-binding Ig-like lectin 9 (Siglec-9) is constitutively expressed on neutrophi...
Both pathogen- and tissue damage-associated molecular patterns induce inflammation through toll-like...
SummaryAtherosclerosis is initiated and sustained by hypercholesterolemia, which results in the gene...
Background: Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that...