Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure
- Schmitt, Matthias
- Gunaruwan, Prasad
- Payne, Nicola
- Taylor, Justin
- Lee, Leong
- Broadley, Andrew J M
- Nightingale, Angus K
- Cockcroft, John R
- Struthers, Allan D
- Tyberg, John V
- Frenneaux, Michael P
Publication date
January 2004
DOI ISSN
1079-5642 Citation count (estimate)
25Abstract
Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects
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