A series of 3-hydroxymethyl derivatives of squalestatin 1 was prepared as inhibitors of squalene synthase. Potent in vitro inhibitory activity is retained in those analogues which possess C-6 and C-1 substituents analogous to those found in 1
Abstract: Enzymatic cyclizations of squalene and oxidosqualene lead to sterols and other triterpenoi...
This paper concerns the synthesis of various simplified analogues of the novel anti-microbial agent,...
A series of 6-polyaminosteroid analogues of squalamine were synthesized with moderate to good yields...
In squalestatins possessing at C6 either a 4,6-dimethyloctenoate ester or a hydroxyl group, the 5-ca...
Squalestatin analogues modified at C3 were prepared and evaluated for their ability to inhibit rat l...
Squalestatins without either the hydroxy group at C-4 or the carboxylic acid at C-3 or C-4 were prep...
The zaragozic acids/squalestatins are a family of bicyclic tricarboxylic acids, isolated from a ser...
Zaragozic acids (or squalestatins) are very potent inhibitors of squalene synthase. They or simpler ...
Squalene synthase catalyzes the reductive dimerization of two molecules of farnesyl pyrophosphate to...
There is an urgent need for the development of new drugs for the treatment of tropical parasitic dis...
La squalamine est un polyaminostérol 3 -N-[3N-(4-aminobutyl)aminopropyl] aminocholestan-7 -ol-24R-su...
Abstract: Enzymatic cyclizations of squalene and oxidosqualene lead to sterols and other triterpenoi...
This paper concerns the synthesis of various simplified analogues of the novel anti-microbial agent,...
A series of 6-polyaminosteroid analogues of squalamine were synthesized with moderate to good yields...
In squalestatins possessing at C6 either a 4,6-dimethyloctenoate ester or a hydroxyl group, the 5-ca...
Squalestatin analogues modified at C3 were prepared and evaluated for their ability to inhibit rat l...
Squalestatins without either the hydroxy group at C-4 or the carboxylic acid at C-3 or C-4 were prep...
The zaragozic acids/squalestatins are a family of bicyclic tricarboxylic acids, isolated from a ser...
Zaragozic acids (or squalestatins) are very potent inhibitors of squalene synthase. They or simpler ...
Squalene synthase catalyzes the reductive dimerization of two molecules of farnesyl pyrophosphate to...
There is an urgent need for the development of new drugs for the treatment of tropical parasitic dis...
La squalamine est un polyaminostérol 3 -N-[3N-(4-aminobutyl)aminopropyl] aminocholestan-7 -ol-24R-su...
Abstract: Enzymatic cyclizations of squalene and oxidosqualene lead to sterols and other triterpenoi...
This paper concerns the synthesis of various simplified analogues of the novel anti-microbial agent,...
A series of 6-polyaminosteroid analogues of squalamine were synthesized with moderate to good yields...
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