Dishevelled (Dsh) is a key signaling molecule in the canonical Wnt pathway. Although the mechanism by which Dsh transduces a Wnt signal remains elusive, the subcellular localization of Dsh may be critical for its function. In the early sea urchin embryo, Dsh is concentrated in punctate structures within the cytoplasm of vegetal blastomeres. In these cells, Dsh stabilizes beta-catenin and causes it to accumulate in nuclei, resulting in the activation of transcriptional gene regulatory networks that drive mesoderm and endoderm formation. Here, we present a systematic mutational analysis of Lytechinus variegatus Dsh (LvDsh) that identifies motifs required for its vegetal cortical localization (VCL). In addition to a previously identified lipid...
AbstractWe discuss recent progress in understanding how cell fates are specified along the animal–ve...
AbstractThe mechanism of animal–vegetal (AV) axis formation in the sea urchin embryo is incompletely...
AbstractIn the sea urchin embryo, specification of the endomesoderm is accomplished by the activity ...
AbstractDishevelled (Dsh) is a key signaling molecule in the canonical Wnt pathway. Although the mec...
Dishevelled (Dsh) is a key signaling molecule in the canonical Wnt pathway. Although the mechanism b...
Pattern formation along the animal-vegetal (AV) axis in sea urchin embryos is initiated when canonic...
Pattern formation along the animal-vegetal (AV) axis in sea urchin embryos is initiated when canonic...
<div><p>Pattern formation along the animal-vegetal (AV) axis in sea urchin embryos is initiated when...
beta-Catenin has a central role in the early axial patterning of metazoan embryos. In the sea urchin...
Wnt signaling plays a central role in establishing anterior-posterior (AP) polarity in metazoan embr...
Canonical Wnt/β-catenin (cWnt) signaling is a crucial regulator of development and Dishevelled (Dsh/...
Data from diverse species within the deuterostomes (mouse, frog, fish, amphioxus, hemichordate, asci...
International audienceIn the sea urchin, entry of β-catenin into the nuclei of the vegetal cells at ...
Abstract The anterior neuroectoderm (ANE) in many deuterostome embryos (echinoderms, hemichordates, ...
Key words: animal-vegetal axis; cell fate specification; endomesoderm; β-catenin; protein turnover E...
AbstractWe discuss recent progress in understanding how cell fates are specified along the animal–ve...
AbstractThe mechanism of animal–vegetal (AV) axis formation in the sea urchin embryo is incompletely...
AbstractIn the sea urchin embryo, specification of the endomesoderm is accomplished by the activity ...
AbstractDishevelled (Dsh) is a key signaling molecule in the canonical Wnt pathway. Although the mec...
Dishevelled (Dsh) is a key signaling molecule in the canonical Wnt pathway. Although the mechanism b...
Pattern formation along the animal-vegetal (AV) axis in sea urchin embryos is initiated when canonic...
Pattern formation along the animal-vegetal (AV) axis in sea urchin embryos is initiated when canonic...
<div><p>Pattern formation along the animal-vegetal (AV) axis in sea urchin embryos is initiated when...
beta-Catenin has a central role in the early axial patterning of metazoan embryos. In the sea urchin...
Wnt signaling plays a central role in establishing anterior-posterior (AP) polarity in metazoan embr...
Canonical Wnt/β-catenin (cWnt) signaling is a crucial regulator of development and Dishevelled (Dsh/...
Data from diverse species within the deuterostomes (mouse, frog, fish, amphioxus, hemichordate, asci...
International audienceIn the sea urchin, entry of β-catenin into the nuclei of the vegetal cells at ...
Abstract The anterior neuroectoderm (ANE) in many deuterostome embryos (echinoderms, hemichordates, ...
Key words: animal-vegetal axis; cell fate specification; endomesoderm; β-catenin; protein turnover E...
AbstractWe discuss recent progress in understanding how cell fates are specified along the animal–ve...
AbstractThe mechanism of animal–vegetal (AV) axis formation in the sea urchin embryo is incompletely...
AbstractIn the sea urchin embryo, specification of the endomesoderm is accomplished by the activity ...